Pencillin G Sodium

Indications
Oral
Prophylaxis of recurrent rheumatic fever
Adult: 250 mg bid.
Child: <5 yr: 125 mg bid; ≥5 yr: 250 mg bid.
Renal impairment: Dose adjustment may be necessary.
Oral
Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas
Adult: 125-250 mg every 6-8 hr for 10 days. For streptococcal pharyngitis: 500 mg 3-4 times daily for 10 days.
Child: For streptococcal pharyngitis: 250 mg bid-tid for 10 days.
Renal impairment: Dose adjustment may be necessary.
Oral
Pneumococcal infections of the respiratory tract, including otitis media
Adult: Mild to moderately severe: 250-500 mg every 6 hr until the patient is afebrile for at least 2 days.
Renal impairment: Dose adjustment may be necessary.
Oral
Staphylococcal infections of the skin and soft tissue
Adult: 250-500 mg every 6-8 hr.
Renal impairment: Dose adjustment may be necessary.
Oral
Fusospirochetosis (Vincent's infection) of the oropharynx
Adult: 250-500 mg every 6-8 hr.
Renal impairment: Dose adjustment may be necessary.

Special Populations: Dosage may need to be modified in severe renal impairment.
Contraindications
Hypersensitivity to penicillins.
Warnings / Precautions
Monitor renal and haematologic systems periodically during prolonged therapy or if high dose is used. Use may result in overgrowth of nonsusceptible organisms. Cross-sensitivity with cephalosporins may occur. History of significant allergies and/or asthma. Pregnancy and lactation.
Adverse Reactions
Nausea, vomiting, epigastric distress, diarrhoea, black hairy tongue; skin eruptions (maculopapular to exfoliative dermatitis), urticaria and other serum-sickness like reactions, laryngeal oedema; fever, eosinophilia.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Reduced absorption with neomycin. Levels/effects may be increased with probenecid. May reduce efficacy of estrogen-containing oral contraceptives.
Potentially Fatal: Increased risk of anaphylactic reactions with nadolol and propranolol.
See Below for More phenoxymethylpenicillin Drug Interactions
Lab Interactions
May interfere with: Diagnostic tests for urinary glucose using copper sulfate; direct Coombs' test; test for urinary or serum proteins; test for uric acid; urinary aminohippurate sodium and phenolsulfonphthalein excretion tests; diagnostic tests that use bacteria.
Food Interactions
Absorption may be slightly affected by food.
Mechanism of Actions
Phenoxymethylpenicillin inhibits the final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane, thus inhibiting bacterial cell wall synthesis. It may be less active against some susceptible organisms, particularly gram-negative bacteria. It is suitable for mild to moderate infections, not for chronic, severe or deep-seated infections.
Absorption: Rapidly, although variably absorbed from the GI tract; about 60% of an oral dose absorbed. Calcium and potassium salts are better absorbed than the free acid. Peak plasma concentrations in 30-60 min after a 500-mg dose.
Distribution: Protein-binding: About 80%. Widely distributed into body tissues; crosses the placenta and distributed in milk.
Metabolism: Hepatic.
Excretion: Primarily via urine (as unchanged drug and metabolites); via bile (small amounts). Plasma half-life: 30-60 min; may be increased to about 4 hr in severe renal impairment.
Administration
Phenoxymethylpenicillin: Should be taken on an empty stomach. (Take on an empty stomach 1 hr before or 2 hr after meals.)
Storage Conditions
Oral: Store at 20-25°C (68-77°F). Solution must be stored in a refrigerator after reconstitution. Discard any unused solution after 14 days.
ATC Classification
J01CE02 - phenoxymethylpenicillin ; Belongs to the class of beta-lactamase sensitive penicillins. Used in the systemic treatment of infections.
Storage
Oral: Store at 20-25°C (68-77°F). Solution must be stored in a refrigerator after reconstitution. Discard any unused solution after 14 days.
Available As
  • Pencillin G Sodium 1,00,000 units
  • Penicillin G Sodium 10,00,000 units
  • Pencillin G Sodium 100,000 units
  • Penicillin G Sodium 100000 units
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  • Penicillin V (Phenoxymethyl Penicillin) 125 mg
  • Procaine Pencillin 13.64 mg
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  • Procaine Pencillin 2% w/v
  • Penicillin G Potassium 200,000 units
  • Penicillin G Potassium 200000 iu
  • Penicillin G Sodium 200000 units
  • Penicillin G Potassium 200000 units
  • Penicillin V (Phenoxymethyl Penicillin) 250 mg
  • Procaine Pencillin 3 million units
  • Procaine Pencillin 3,00,000 units
  • Procaine Pencillin 30,00,000 units
  • Procaine Pencillin 300,000 units
  • Procaine Pencillin 300000 units
  • Procaine Pencillin 3000000 units
  • Penicillin G Potassium 400000 iu
  • Pencillin G Sodium 400000 units
  • Penicillin G Potassium 400000 units
  • Penicillin G Sodium 500,000 units
  • Penicillin G Sodium 500000 iu
  • Penicillin G Sodium 500000 units
  • Procaine Pencillin 600000 units
  • Penicillin G Potassium 800000 iu
  • Penicillin G Potassium 800000 units
  • Procaine Pencillin 800000 units
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