Indications |
Oral Prophylaxis of recurrent rheumatic fever Adult: 250 mg bid. Child: <5 yr: 125 mg bid; ≥5 yr: 250 mg bid. Renal impairment: Dose adjustment may be necessary. Oral Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas Adult: 125-250 mg every 6-8 hr for 10 days. For streptococcal pharyngitis: 500 mg 3-4 times daily for 10 days. Child: For streptococcal pharyngitis: 250 mg bid-tid for 10 days. Renal impairment: Dose adjustment may be necessary. Oral Pneumococcal infections of the respiratory tract, including otitis media Adult: Mild to moderately severe: 250-500 mg every 6 hr until the patient is afebrile for at least 2 days. Renal impairment: Dose adjustment may be necessary. Oral Staphylococcal infections of the skin and soft tissue Adult: 250-500 mg every 6-8 hr. Renal impairment: Dose adjustment may be necessary. Oral Fusospirochetosis (Vincent's infection) of the oropharynx Adult: 250-500 mg every 6-8 hr. Renal impairment: Dose adjustment may be necessary. Special Populations: Dosage may need to be modified in severe renal impairment. |
Contraindications |
Hypersensitivity to penicillins. |
Warnings / Precautions |
Monitor renal and haematologic systems periodically during prolonged therapy or if high dose is used. Use may result in overgrowth of nonsusceptible organisms. Cross-sensitivity with cephalosporins may occur. History of significant allergies and/or asthma. Pregnancy and lactation. |
Adverse Reactions |
Nausea, vomiting, epigastric distress, diarrhoea, black hairy tongue; skin eruptions (maculopapular to exfoliative dermatitis), urticaria and other serum-sickness like reactions, laryngeal oedema; fever, eosinophilia. Potentially Fatal: Anaphylaxis. |
Drug Interactions |
Reduced absorption with neomycin. Levels/effects may be increased with probenecid. May reduce efficacy of estrogen-containing oral contraceptives. Potentially Fatal: Increased risk of anaphylactic reactions with nadolol and propranolol. See Below for More phenoxymethylpenicillin Drug Interactions |
Lab Interactions |
May interfere with: Diagnostic tests for urinary glucose using copper sulfate; direct Coombs' test; test for urinary or serum proteins; test for uric acid; urinary aminohippurate sodium and phenolsulfonphthalein excretion tests; diagnostic tests that use bacteria. |
Food Interactions |
Absorption may be slightly affected by food. |
Mechanism of Actions |
Phenoxymethylpenicillin inhibits the final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane, thus inhibiting bacterial cell wall synthesis. It may be less active against some susceptible organisms, particularly gram-negative bacteria. It is suitable for mild to moderate infections, not for chronic, severe or deep-seated infections. Absorption: Rapidly, although variably absorbed from the GI tract; about 60% of an oral dose absorbed. Calcium and potassium salts are better absorbed than the free acid. Peak plasma concentrations in 30-60 min after a 500-mg dose. Distribution: Protein-binding: About 80%. Widely distributed into body tissues; crosses the placenta and distributed in milk. Metabolism: Hepatic. Excretion: Primarily via urine (as unchanged drug and metabolites); via bile (small amounts). Plasma half-life: 30-60 min; may be increased to about 4 hr in severe renal impairment. |
Administration |
Phenoxymethylpenicillin: Should be taken on an empty stomach. (Take on an empty stomach 1 hr before or 2 hr after meals.) |
Storage Conditions |
Oral: Store at 20-25°C (68-77°F). Solution must be stored in a refrigerator after reconstitution. Discard any unused solution after 14 days. |
ATC Classification |
J01CE02 - phenoxymethylpenicillin ; Belongs to the class of beta-lactamase sensitive penicillins. Used in the systemic treatment of infections. |
Storage |
Oral: Store at 20-25°C (68-77°F). Solution must be stored in a refrigerator after reconstitution. Discard any unused solution after 14 days. |
Available As |
|
Pencillin G Sodium
Post Review about Pencillin G Sodium Click here to cancel reply.
Pencillin G Sodium Containing Brands
Pencillin G Sodium is used in following diseases
Drug - Drug Interactions of Pencillin G Sodium
Latest News
- FDA approves Ruconest for treatment of hereditary angioedema
- FDA recommend against aspirin to prevent First Heart Attacks
- FDA approves Pomalyst (pomalidomide) for advanced multiple myeloma
- FDA approves three new drug treatments for type 2 diabetes
- Long-term consequences of vaginal delivery on the pelvic floor
No comments yet.