Indications |
Oral Susceptible infections Adult: 400 mg bid. Renal impairment: Dose reduction may be necessary. Oral Acute uncomplicated cystitis in women Adult: 800 mg as single dose. Renal impairment: Dose reduction may be necessary. Oral Gonococcal urethritis in men Adult: 800 mg as single dose. Renal impairment: Dose reduction may be necessary. Special Populations: Liver disease: In patients with jaundice 400 mg once daily. with ascitis: 400 mg once in 36 hours. Severe renal failure: 400 mg once daily. |
Contraindications |
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation. |
Warnings / Precautions |
Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn. |
Adverse Reactions |
Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction. |
Drug Interactions |
Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin. See Below for More pefloxacin Drug Interactions |
Mechanism of Actions |
Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction. Metabolism: Extensive metabolism; converted to N-desmethylpefloxacin (norfloxacin). Excretion: 8-13 hr (elimination half-life). |
Administration |
Should be taken with food. (Take w/ meals.) |
Storage Conditions |
Oral: Store at room temperature. Keep away from excess heat and moisture. |
ATC Classification |
J01MA03 - pefloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections. |
Storage |
Oral: Store at room temperature. Keep away from excess heat and moisture. |
Available As |
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Pefloxacin
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Pefloxacin Containing Brands
Pefloxacin is used in following diseases
Drug - Drug Interactions of Pefloxacin
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