Pefloxacin

Indications
Oral
Susceptible infections
Adult: 400 mg bid.
Renal impairment: Dose reduction may be necessary.
Oral
Acute uncomplicated cystitis in women
Adult: 800 mg as single dose.
Renal impairment: Dose reduction may be necessary.
Oral
Gonococcal urethritis in men
Adult: 800 mg as single dose.
Renal impairment: Dose reduction may be necessary.

Special Populations: Liver disease: In patients with jaundice 400 mg once daily. with ascitis: 400 mg once in 36 hours. Severe renal failure: 400 mg once daily.
Contraindications
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.
Warnings / Precautions
Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn.
Adverse Reactions
Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction.
Drug Interactions
Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin.
See Below for More pefloxacin Drug Interactions
Mechanism of Actions
Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction.
Metabolism: Extensive metabolism; converted to N-desmethylpefloxacin (norfloxacin).
Excretion: 8-13 hr (elimination half-life).
Administration
Should be taken with food. (Take w/ meals.)
Storage Conditions
Oral: Store at room temperature. Keep away from excess heat and moisture.
ATC Classification
J01MA03 - pefloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Storage
Oral: Store at room temperature. Keep away from excess heat and moisture.
Available As
  • Pefloxacin 0.3%
  • Pefloxacin 0.3% w/v
  • Pefloxacin 100 mg
  • Pefloxacin 200 mg
  • Pefloxacin 400 mg
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