Oxymetazoline

Indications
 Nasal
Nasal congestion
Adult: As 0.05% solution: Spray 1-3 times into each nostril bid.
Child: ≥6 yr: Instill or spray 0.05% solution 1-3 times into each nostril bid.
Ophthalmic
Conjunctival decongestant
Adult: Instil 1-2 drops of 0.025% solution into the eye(s) 6 hrly when necessary.
Child: ≥6 yr: Instill 1-2 drops of 0.025% solution into the eye(s) 6 hrly when necessary.
Contraindications
 Glaucoma; hyperthyroidism, heart disease (including angina), hypertension, advanced arteriosclerotic conditions. Children <6 yr.
Warnings / Precautions
 Pregnancy, lactation. Difficulty in urination secondary to prostate enlargement; DM.
Adverse Reactions
 Nasal drops or spray: Local stinging or burning, sneezing, dryness of mouth and throat. Prolonged or frequent use may cause rebound congestion. Headache, insomnia, tachycardia, hypertension, nervousness, nausea, dizziness, palpitation, arrhythmia. Eye drops: Dryness of eye.
Drug Interactions
 Potentially Fatal: Hypertensive crisis with MAOIs.
See Below for More oxymetazoline Drug Interactions
Mechanism of Actions
 Oxymetazoline is a direct-acting sympathomimetic which has vasoconstrictor effect on mucosal blood vessels when applied topically and in turn reduces oedema of the nasal mucosa.
Duration: Up to 12 hr.
ATC Classification
 R01AA05 - oxymetazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
R01AB07 - oxymetazoline ; Belongs to the class of topical sympathomimetic combination preparations, excluding corticosteroids. Used as nasal decongestants.
S01GA04 - oxymetazoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
Available As
  • Oxymetazoline 0.025%
  • Oxymetazoline 0.025% w/v
  • Oxymetazoline 0.05%
  • Oxymetazoline 0.05% w/v
  • Oxymetazoline 0.1 mg
  • Oxymetazoline 0.25 mg
  • Oxymetazoline 0.5 mg
  • Oxymetazoline 0.5% w/v
  • Oxymetazoline 5 mg

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