Orlistat

Indications
Oral
Obesity
Adult: 120 mg tid with each main meal containing fat; omit dose if meal is occasionally missed or has no fat.
Child: ≥12 yr: 120 mg tid with each main meal containing fat; omit dose if meal is occasionally missed or has no fat.
Contraindications
Chronic malabsorption syndrome. Cholestasis. Lactation.
Warnings / Precautions
Distribute daily intake of fat over 3 main meals. Fat-soluble vitamins supplements may be required during long-term therapy. Discontinue use if 5% body wt loss is not achieved during the first 12 wk. History of hyperoxaluria or calcium oxalate nephrolithiasis. DM. Pregnancy.
Adverse Reactions
Faecal urgency and incontinence, flatulence, fatty stools or discharge, increased defecation; headache, anxiety, fatigue, menstrual irregularities; abdominal pain/discomfort.
Potentially Fatal: Anaphylaxis; angioedema.
Drug Interactions
May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin.
See Below for More orlistat Drug Interactions
Mechanism of Actions
Orlistat is a reversible gastric and pancreatic lipase inhibitor. It exerts antiobesity effects by limiting the absorption of dietary fats through inhibition of triglyceride hydrolysis. It does not exert appetite suppressant effects.
Onset: 24-48 hr.
Duration: 48-72 hr.
Absorption: Minimally absorbed (oral).
Metabolism: Metabolised to inactive metabolites within the GI wall.
Excretion: Mainly via faeces (83% as unchanged drug).
Administration
Should be taken with food. (Take immediately before or during or up to 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted.)
Storage Conditions
Oral: Store at 15-30°C (59-86°F).
ATC Classification
A08AB01 - orlistat ; Belongs to the class of peripherally acting antiobesity products.
Storage
Oral: Store at 15-30°C (59-86°F).
Available As
  • Orlistat 120 mg
  • Orlistat 27 mg
  • Orlistat 60 mg
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