Orlistat

Indications
Oral
Obesity
Adult: 120 mg tid with each main meal containing fat; omit dose if meal is occasionally missed or has no fat.
Child: ≥12 yr: 120 mg tid with each main meal containing fat; omit dose if meal is occasionally missed or has no fat.
Contraindications
Chronic malabsorption syndrome. Cholestasis. Lactation.
Warnings / Precautions
Distribute daily intake of fat over 3 main meals. Fat-soluble vitamins supplements may be required during long-term therapy. Discontinue use if 5% body wt loss is not achieved during the first 12 wk. History of hyperoxaluria or calcium oxalate nephrolithiasis. DM. Pregnancy.
Adverse Reactions
Faecal urgency and incontinence, flatulence, fatty stools or discharge, increased defecation; headache, anxiety, fatigue, menstrual irregularities; abdominal pain/discomfort.
Potentially Fatal: Anaphylaxis; angioedema.
Drug Interactions
May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin.
See Below for More orlistat Drug Interactions
Mechanism of Actions
Orlistat is a reversible gastric and pancreatic lipase inhibitor. It exerts antiobesity effects by limiting the absorption of dietary fats through inhibition of triglyceride hydrolysis. It does not exert appetite suppressant effects.
Onset: 24-48 hr.
Duration: 48-72 hr.
Absorption: Minimally absorbed (oral).
Metabolism: Metabolised to inactive metabolites within the GI wall.
Excretion: Mainly via faeces (83% as unchanged drug).
Administration
Should be taken with food. (Take immediately before or during or up to 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted.)
Storage Conditions
Oral: Store at 15-30°C (59-86°F).
ATC Classification
A08AB01 - orlistat ; Belongs to the class of peripherally acting antiobesity products.
Storage
Oral: Store at 15-30°C (59-86°F).
Available As
  • Orlistat 120 mg
  • Orlistat 27 mg
  • Orlistat 60 mg
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    Orlistat Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Capsule Lipophage (60 mg) Franco-Indian Pharmaceuticals Pvt. Ltd. 1 Capsule
    ₹ 21.87
    10 Capsule
    ₹ 218.65
  • More Information Orlistat 60 mg
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    Capsule Obfree (60 mg) Bioplasma Immunological Research Pvt. Ltd. 1 Capsule
    ₹ 22.00
    10 Capsule
    ₹ 220.00
  • More Information Orlistat 60 mg
  • See Brands having above combination
    Capsule O Stat (60 mg) Aristo Pharmaceuticals Pvt Ltd. 1 Tablet
    ₹ 15.00
    10 Tablet
    ₹ 150.00
  • More Information Orlistat 60 mg
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    Capsule Orlean (60 mg) Eris (Enzo Biopharma) 1 Capsule
    ₹ 22.00
    10 Capsule
    ₹ 220.00
  • More Information Orlistat 60 mg
  • See Brands having above combination
    Capsule Orlica (60 mg) Azuca (Torrent Pharmaceuticals Ltd.) 1 Capsule
    ₹ 19.10
    10 Capsule
    ₹ 191.00
  • More Information Orlistat 60 mg
  • See Brands having above combination
    Tablet Redufat (27 mg) Titan Bioscience Pvt Ltd 1 Tablet
    ₹ 10.70
    10 Tablet
    ₹ 107.00
  • More Information Orlistat 27 mg
  • See Brands having above combination
    Tablet Redufat (60 mg) Titan Bioscience Pvt Ltd 1 Tablet
    ₹ 17.00
    10 Tablet
    ₹ 170.00
  • More Information Orlistat 60 mg
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    Capsule Vyfat (60 mg) Intas Pharmaceuticals Ltd. 1 Capsule
    ₹ 20.00
    10 Capsule
    ₹ 200.00
  • More Information Orlistat 60 mg
  • See Brands having above combination
    Capsule Zerofat (120 mg) Discovery (Mankind Pharmaceuticals Pvt. Ltd.) 1 Capsule
    ₹ 19.99
    10 Capsule
    ₹ 199.90
  • More Information Orlistat 120 mg
  • See Brands having above combination
    Capsule Zerofat (60 mg) Discovery (Mankind Pharmaceuticals Pvt. Ltd.) 1 Capsule
    ₹ 9.99
    10 Capsule
    ₹ 99.90
  • More Information Orlistat 60 mg
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    Orlistat is used in following diseases

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    Drug - Drug Interactions of Orlistat
    Interaction
    Moderate, Consider therapy modification Vitamin A vs Orlistat
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    Moderate, Consider therapy modification Paricalcitol vs Orlistat
    Moderate, Consider therapy modification Vitamin D2 (ergocalciferol) vs Orlistat
    Moderate, Consider therapy modification Calcipotriol (calcipotriene) vs Orlistat
    Moderate, Consider therapy modification Alfacalcidol vs Orlistat
    Minor, Monitor Therapy Orlistat vs Warfarin
    Moderate, Consider therapy modification Orlistat vs Vitamins (Fat Soluble)
    Moderate, Consider therapy modification Orlistat vs Vitamin D Analogs
    Moderate, Consider therapy modification Orlistat vs Paricalcitol
    Pages: 1 2 3 Next