Olopatadine

Indications
Nasal
Allergic rhinitis
Adult: ≥12 yr: As 0.6% nasal spray: Instill 2 sprays into each nostril twice daily.
Ophthalmic
Allergic conjunctivitis
Adult: As 0.1% solution: 1 or 2 drops in the affected eye(s) bid at an interval of 6-8 hr. Alternatively, as a 0.2% solution: 1 drop in the affected eye(s) once daily.
Child: ≥3 yr: As 0.1% solution: 1 or 2 drops in the affected eye(s) bid at an interval of 6-8 hr. Alternatively, as a 0.2% solution: 1 drop in the affected eye(s) once daily.
Contraindications
Hypersensitivity. Ophthalmic: Children <3 yr. Nasal: Children <12 yr.
Warnings / Precautions
Pregnancy, lactation. Ophthalmic: Remove contact lenses prior to eye admin. Reinsert soft contact lenses 10 min after admin.
Adverse Reactions
Ophthalmic: Headache; asthenia; cold syndrome; pharyngitis; rhinitis; sinusitis; dysgeusia; ocular burning or stinging; dry eye; foreign body sensation; hyperaemia; keratitis; lid oedema; ocular pruritus; blurred vision. Nasal: Bitter taste, nasal ulceration, epistaxis, drowsiness.
Mechanism of Actions
Olopatadine is a relatively selective histamine H1-receptor antagonist and inhibits the release of histamine from mast cells. It shares many of the pharmacologic effects of mast cell stabilisers.
Absorption: Ophthalmic: Little systemic absorption.
Distribution: Protein-binding: 55%
Metabolism: Not extensively metabolised.
Excretion: Via urine: 60-70 %, via faeces: 17 %
Storage Conditions
Nasal: Store at 4 to 25 °C. Ophthalmic: Store at 2-25°C.
ATC Classification
R01AC08 - olopatadine ; Belongs to the class of topical antiallergic preparations, excluding corticosteroids. Used as antiallergic agents.
S01GX09 - olopatadine ; Belongs to the class of other ophthalmologic antiallergics.
Storage
Nasal: Store at 4 to 25 °C. Ophthalmic: Store at 2-25°C.
Available As
  • Olopatadine 0.1%
  • Olopatadine 0.1% w/v
  • Olopatadine 0.10% w/v
  • Olopatadine 0.2%
  • Olopatadine 0.2% w/v
  • Olopatadine 0.5% w/v
  • Olopatadine 1 mg
  • Olopatadine 1%
  • Olopatadine 5 mg
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