Nitazoxanide

Indications
 Oral
Giardiasis, Cryptosporidiosis
Adult: 500 mg every 12 hr for 3 days.
Child: 1-3 yr: 100 mg every 12 hr; 4-11 yr: 200 mg every 12 hr; ≥12 yr: 500 mg every 12 hr. All doses to be taken for 3 days.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Renal and hepatic impairment. Pregnancy and lactation. Children <1 yr.
Adverse Reactions
 Headache, abdominal pain, diarrhoea, nausea, vomiting, allergic reactions, anaemia, anorexia, increased appetite, increased creatinine and LFT, diaphoresis, dizziness, eye and urine discolouration, fever, flatulence, hypertension, infection, malaise, nausea, pruritus, rhinitis, enlarged salivary glands, tachycardia.
Drug Interactions
 May possibly interact with highly protein-bound drugs e.g. warfarin.
See Below for More nitazoxanide Drug Interactions
Food Interactions
 Increased AUC with food.
Mechanism of Actions
 Nitazoxanide is an antiprotozoal agent. Both nitazoxanide and its active metabolite (tizoxanide) interfere with the pyruvate:ferredoxin 2-oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic metabolism in susceptible organisms.
Absorption: Absorbed from the GI tract (oral). Extent of absorption enhanced with food; peak plasma concentrations of tizoxanide and glucuronide metabolite after 1-4 hr.
Distribution: Protein-binding: >99%.
Metabolism: Rapidly hydrolysed to tizoxanide (active desacetyl metabolite) which partially undergoes conjugation, primarily by glucuronidation.
Excretion: Via faeces (2/3 of an oral dose); via urine (remaining dose).
Administration
 Should be taken with food.
Storage Conditions
 Oral: Suspension: Store at 15-30°C (59-86°F). Tablet: Store at room temperature.
ATC Classification
 P01AX11 - nitazoxanide ; Belongs to the class of other agents used in the treatment amoebiasis and other protozoal diseases.
Storage
 Oral: Suspension: Store at 15-30°C (59-86°F). Tablet: Store at room temperature.
Available As
  • Nitazoxanide 10 gm
  • Nitazoxanide 100 mg
  • Nitazoxanide 125 mg
  • Nitazoxanide 200 mg
  • Nitazoxanide 500 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Nitazoxanide


    Nitazoxanide Containing Brands

    We are Developing Our database, More results coming soon.

    Nitazoxanide is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Nitazoxanide

    We are Developing Our database, More results coming soon.