Nicorandil

Indications
 Oral
Angina pectoris
Adult: 10 mg bid, increase if necessary. Usual dose: 10-20 mg bid. May use 5 mg bid for patients prone to headache. Max dose: 30 mg bid.
Hepatic impairment: Dose reduction may be necessary.
Contraindications
 Cardiogenic shock; hypotension; left ventricular failure with low filling pressure; lactation.
Warnings / Precautions
 Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery.
Adverse Reactions
 Headache (usually transitory), flushing, dizziness, nausea, vomiting and weakness. Hypotension and reflex tachycardia at high doses.
Drug Interactions
 Hypotensive interaction may occur with alcohol, TCAs, antihypertensives and other vasodilators.
Potentially Fatal: Enhanced hypotensive effect with sildenafil and other phosphodiesterase type-5 inhibitors.
See Below for More nicorandil Drug Interactions
Mechanism of Actions
 Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylate cyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.
Absorption: Absorbed well from the GI tract (oral); peak plasma concentrations after 30-60 min.
Distribution: Protein-binding: Slightly bound.
Metabolism: Denitration.
Excretion: Via urine (as metabolites); 1 hr (elimination half-life).
Administration
 May be taken with or without food.
ATC Classification
 C01DX16 - nicorandil ; Belongs to the class of other vasodilators used in cardiac diseases.
Available As
  • Nicorandil 10 mg
  • Nicorandil 2 mg
  • Nicorandil 20 mg
  • Nicorandil 48 mg
  • Nicorandil 5 mg
  • Nicorandil 50 mg

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    One Response to Nicorandil

    1. avishek August 13, 2014 at 2:48 pm #

      Summery

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