Natamycin

Indications
 Oral
Intestinal candidiasis
Adult: 100 mg 4 times daily.
Child: 100 mg bid.
Oral
Oral candidiasis
Adult: One 10-mg loz every 4-6 hr.
Ophthalmic
Blepharitis, conjunctivitis and keratitis
Adult: Ophthamic suspension 5%: Instil 1 drop in conjunctival sac every 1-2 hr; reduce to 1 drop 6-8 times a day after 3-4 days. Duration of treatment: 2-3 wk. Ointment 1%: Apply bid-tid.
Vaginal
Trichomoniasis
Adult: One 25-mg vaginal tablet daily for 20 days.
Vaginal
Vulvovaginal candidiasis
Adult: One 100-mg vaginal tablet for 3-6 days.
Topical/Cutaneous
Skin fungal infections
Adult: Apply 2% cream to the affected area once or several times a day.
Topical/Cutaneous
Nail fungal infections
Adult: Apply 2% cream to the affected area once or several times a day.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Pregnancy and lactation. Porphyria.
Adverse Reactions
 GI disturbances (oral). Irritation (local). Conjunctival chemosis and hyperaemia (ophthalmic).
Drug Interactions
 Ophthalmic: May increase spread of fungal eye infection when used with topical corticosteroid.
See Below for More natamycin Drug Interactions
Mechanism of Actions
 Natamycin is a polyene antifungal antibiotic which acts by increasing cell membrane permeability in susceptible fungi. It is active against Candida and Fusarium spp, and against the protozoan Trichomonas vaginalis.
Absorption: Poorly absorbed from the GI tract (<2%). Not absorbed through the skin or mucous membranes (topical). Present in therapeutic concentrations in corneal stroma but not in intraocular fluid (ocular).
Storage Conditions
 Ophthalmic: Ophthalmic suspension: Store at 8-24°C (46-75°F); do not freeze. Topical/Cutaneous: Store at 15-25°C.
ATC Classification
 D01AA02 - natamycin ; Belongs to the class of antibiotics. Used in the topical treatment of fungal infection.
A01AB10 - natamycin ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
G01AA02 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of gynecological infections.
A07AA03 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
S01AA10 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
Storage
 Ophthalmic: Ophthalmic suspension: Store at 8-24°C (46-75°F); do not freeze. Topical/Cutaneous: Store at 15-25°C.
Available As
  • Natamycin 0.50% w/v
  • Natamycin 100 mg
  • Natamycin 5%
  • Natamycin 5% w/v
  • Natamycin 50 mg

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