Mupirocin

Indications
 Nasal
Eradication of nasal colonisation with Staphylococci aureus
Adult: As 2% nasal ointment: Apply into each nostril bid-tid for a max of 7 days. After application, the nostrils should be closed by pressing together and releasing the sides of the nose.
Child: Adolescents (≥12 yr): Apply nasal ointment to the inner surface of both nostrils 2-3 times daily for 5-14 days. After application, the nostrils should be closed by pressing together and releasing the sides of the nose for approximately 1 min.
Topical/Cutaneous
Impetigo
Adult: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Child: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Topical/Cutaneous
Secondary skin infections
Adult: Apply a 2% cream tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Child: Apply a 2% ointment tid for 10 days. If no improvement is seen after 3-5 days, consider alternative treatment.
Contraindications
 Hypersensitivity to mupirocin or polyethylene glycol.
Warnings / Precautions
 Mucosal surfaces of eye; renal impairment; extensive burns or open wounds. Pregnancy, lactation, children <3 mth.
Adverse Reactions
 Burning, stinging, pain, itching, erythema, dryness, tenderness, dermatitis and rash.
Mechanism of Actions
 Mupirocin inhibits protein synthesis of the bacteria by binding to isoleucyl transfer RNA-synthetase. It is active against gram-positive and some gram-negative bacteria.
Absorption: Minimal systemic absorption through intact skin (<0.3%).
Distribution: Protein-binding: 95%
Metabolism: Hepatic, converted to monic acid.
Excretion: Urine; 17-36 min (elimination half-life).
Storage Conditions
 Nasal: Store at or below 25°. Do not freeze. Topical/Cutaneous: Store at or below 25°. Do not freeze.
ATC Classification
 D06AX09 - mupirocin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
R01AX06 - mupirocin ; Belongs to the class of other nasal preparations for topical use.
Storage
 Nasal: Store at or below 25°. Do not freeze. Topical/Cutaneous: Store at or below 25°. Do not freeze.
Available As
  • Mupirocin 2%
  • Mupirocin 2% mg
  • Mupirocin 2% w/w

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