Mometasone

Indications
 Nasal
Treatment and prophylaxis of allergic rhinitis
Adult: 100 mcg in each nostril once daily, increased to 200 mcg into each nostril once daily if needed. Maintenance: 50 mcg in each nostril daily.
Child: 2-11 yr: 50 mcg in each nostril daily; ≥12 yr: 100 mcg in each nostril daily.
Nasal
Nasal polyps
Adult: 100 mcg in each nostril once daily; may increase to bid after 5-6 wk if needed.
Inhalation
Asthma prophylaxis
Adult: Mild to moderate: Initially, 400 mcg once daily in the evening. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Child: Mild to moderate: Initially, 400 mcg once daily. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.1% cream/ointment/lotion: Apply onto the affected areas as directed.
Child: Cream/Ointment: ≥2 yr: Apply thin film to affected area once daily. Do not use for > 3 wk. Lotion: ≥12 yr: Apply a few drops to affected area once daily.
Warnings / Precautions
 Discontinue if irritation or sensitisation occurs. Systemic absorption increases when area of application is extensive or an occlusive dressing is used. Pregnancy and lactation. DM, hepatic and renal diseases, myasthenia gravis, CV disease, ocular diseases, osteoporosis, GI diseases, history of seizure disorders. Not for status asthmaticus or relief of acute bronchospasm. Requires dosage adjustments with thyroid status. May reduce growth velocity in children; monitor growth. Taper withdrawal.
Adverse Reactions
 Nasal/Oral inhalation: Headache, fatigue, depression; musculoskeletal pain, arthalgia; sinusitis, rhinitis, upper respiratory infection, pharyngitis, cough, epistaxis; viral infection, nasal and oral candidiasis; chest pain; abdominal pain, dry throat, vomiting, diarrhoea, dyspepsia, flatulence, gastroenteritis, nausea, vomiting; dysmenorrhoea; back pain, myalgia; conjunctivitis; earache, otitis media; asthma, bronchitis, dysphonia; nasal irritation, burning and septal perforation; wheezing; nasal ulcers; growth suppression. Topical: Bacterial skin infection, burning, furunculosis, pruritus, skin atrophy, tingling/stinging, folliculitis, moniliasis, paraesthesia, skin depigmentation, rosacea, cataract, growth suppression.
Potentially Fatal: Adrenal suppression, immunosuppression, Kaposi's sarcoma in prolonged periods, anaphylaxis.
Overdose Reactions
 Systemic corticosteroid effects.
Drug Interactions
 Increased risk of hypokalaemia with amphotericin B, potassium-wasting diuretics. Decreases hypoglycaemic effects of antidiabetic drugs. Increased serum levels with antifungals (imidazole). Increased risk of tendinopathies with fluoroquinolones.
See Below for More mometasone Drug Interactions
Mechanism of Actions
 Mometasone depresses the formation, release and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes and prostaglandin). It inhibits the margination and subsequent cell migration to the injury site, reverses vascular dilatation and permeability, resulting in decreased access of cells to the area of injury.
Absorption: Ointment: 0.7%; increased with occlusive dressings. Nasal spray: Undetectable in plasma. Oral inhalation: <1%.
Distribution: Protein-binding: 98-99%.
Metabolism: Hepatic.
Excretion: Via faeces, bile, urine.
Storage Conditions
 Inhalation: Store at 15-30°C. Discard when counter reads "0" or 45 days after opening. Nasal: Store at 15-30°C. Protect from light. Topical/Cutaneous: Cream: Store at 2-25°C. Lotion: Store at 2-30°C. Ointment: Store at 15-30°C.
ATC Classification
 D07AC13 - mometasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
D07XC03 - mometasone ; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
R01AD09 - mometasone ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.
R03BA07 - mometasone ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticoids.
Storage
 Inhalation: Store at 15-30°C. Discard when counter reads "0" or 45 days after opening. Nasal: Store at 15-30°C. Protect from light. Topical/Cutaneous: Cream: Store at 2-25°C. Lotion: Store at 2-30°C. Ointment: Store at 15-30°C.
Available As
  • Mometasone 0.05%
  • Mometasone 0.05% w/v
  • Mometasone 0.05% w/w
  • Mometasone 0.1%
  • Mometasone 0.1% w/v
  • Mometasone 0.1% w/w
  • Mometasone 0.10%
  • Mometasone 0.5% w/v
  • Mometasone 1 mg
  • Mometasone 1% w/w
  • Mometasone 50 mcg

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    One Response to Mometasone

    1. June 5, 2013 at 6:07 pm #

      I am posting one photo told me the name of disease and its treatment.I am using Eczone furoate cream since last 20 days but cant got relief.

      Reply

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