Indications |
Oral Allergic conditions Adult: 10 mg daily. Child: ≥12 yr: 10 mg daily. Elderly: 10 mg daily. |
Contraindications |
Significant cardiac or hepatic disease; electrolyte imbalance, particularly hypokalaemia; known or suspected QT prolongation. Clinically significant bradycardia. |
Warnings / Precautions |
May impair ability to drive or operate machinery. Elderly. Pregnancy (avoid in 1st trimester) and lactation. |
Adverse Reactions |
Dry mouth, diarrhoea, abdominal pain, nausea; transient drowsiness, headache, dizziness; anxiety and depression; raised liver enzymes: low neutrophil count; transient asthenia, increased appetite associated with wt gain; allergic reactions e.g. angioedema, generalised rash/urticaria, pruritus and hypotension; tachycardia, palpitations; vasovagal attack; arthralgia and myalgia. Potentially Fatal: Anaphylaxis. |
Overdose Reactions |
General symptomatic treatment with cardiac monitoring including QT interval and cardiac rhythm for at least 24 hr is recommended. Haemodialysis may not be helpful. |
Drug Interactions |
Antidepressants and anxiolytics may enhance sedative effect. Potent inhibitors of or substrates for the hepatic metabolism of mizolastine (e.g. cimetidine, ciclosporin, nifedipine) may alter its metabolism. Potentially Fatal: Increased risk of cardiac arrhythmias with drugs known to prolong the QT interval e.g. class I and III antiarryhthmics. Increased plasma concentrations with macrolide antibiotics and imidazole antifungals. See Below for More mizolastine Drug Interactions |
Mechanism of Actions |
Mizolastine, a non-sedating antihistamine, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also has mast-cell stabilising properties. Absorption: Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1.5 hr. Distribution: Protein-binding: 98%. Metabolism: By glucuronidation (main pathway) or by cytochrome P450 isoenzyme CYP3A4 forming inactive hydroxylated metabolites. Excretion: 13 hr (elimination half-life). |
Storage Conditions |
Oral: Do not store above 25°C. |
ATC Classification |
R06AX25 - mizolastine ; Belongs to the class of other antihistamines for systemic use. |
Storage |
Oral: Do not store above 25°C. |
Available As |
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Mizolastine
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Mizolastine Containing Brands
Mizolastine is used in following diseases
Drug - Drug Interactions of Mizolastine
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