Indications |
Oral Vitamin K deficiency Adult: 10 mg every 6 hr. Oral Severe hypoprothrombinaemia Adult: 10 mg 3-4 times daily. Intravenous Vitamin K deficiency Adult: 0.03 mcg/kg/day. Child: Infants: 1-5 mcg/kg/day. Intramuscular Severe hypoprothrombinaemia Adult: 2.5-10 mg daily. |
Warnings / Precautions |
Pregnancy. G6PD deficiency, vitamin E deficiency. Neonates, premature infants. Hepatic impairment. Monitor prothrombin time. |
Adverse Reactions |
Facial flushing, sweating, chest constriction/pain, dyspnoea, cyanosis, CV collapse. IM: Severe shock-like reactions, phlebitis, inj site reactions. Potentially Fatal: Anaphylaxis. |
Drug Interactions |
Decreases effects of oral anticoagulants. See Below for More menadione Drug Interactions |
Mechanism of Actions |
Menadione is a synthetic lipid-soluble vitamin K analogue. It is an essential cofactor in the hepatic synthesis of prothrombin (factor II) and other blood clotting factors (factors VII, IX, X and proteins C and S), and in the function of proteins important for bone development (e.g. osteocalcin). Absorption: Requires bile for absorption from the GI tract. Distribution: Accumulates in the liver; does not appear to cross the placenta. |
ATC Classification |
B02BA02 - menadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage. |
Available As |
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Menadione
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Drug - Drug Interactions of Menadione
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