Menadione

Indications
 Oral
Vitamin K deficiency
Adult: 10 mg every 6 hr.
Oral
Severe hypoprothrombinaemia
Adult: 10 mg 3-4 times daily.
Intravenous
Vitamin K deficiency
Adult: 0.03 mcg/kg/day.
Child: Infants: 1-5 mcg/kg/day.
Intramuscular
Severe hypoprothrombinaemia
Adult: 2.5-10 mg daily.
Warnings / Precautions
 Pregnancy. G6PD deficiency, vitamin E deficiency. Neonates, premature infants. Hepatic impairment. Monitor prothrombin time.
Adverse Reactions
 Facial flushing, sweating, chest constriction/pain, dyspnoea, cyanosis, CV collapse. IM: Severe shock-like reactions, phlebitis, inj site reactions.
Potentially Fatal: Anaphylaxis.
Drug Interactions
 Decreases effects of oral anticoagulants.
See Below for More menadione Drug Interactions
Mechanism of Actions
 Menadione is a synthetic lipid-soluble vitamin K analogue. It is an essential cofactor in the hepatic synthesis of prothrombin (factor II) and other blood clotting factors (factors VII, IX, X and proteins C and S), and in the function of proteins important for bone development (e.g. osteocalcin).
Absorption: Requires bile for absorption from the GI tract.
Distribution: Accumulates in the liver; does not appear to cross the placenta.
ATC Classification
 B02BA02 - menadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage.
Available As
  • Menadione 0.1 mg
  • Menadione 0.13 mg
  • Menadione 0.5 mg
  • Menadione 0.56 mg
  • Menadione 0.66 mg
  • Menadione 1 mg
  • Menadione 10 mg
  • Menadione 15 mg
  • Menadione 20 mg
  • Menadione 5 mg
  • Menadione 66.20 mg

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