Mebendazole

Indications
Oral
Ascariasis
Adult: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk.
Child: >1 yr: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk.
Hepatic impairment: Dose reduction may be required.
Oral
Trichuriasis
Adult: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk.
Child: >1 yr: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk.
Hepatic impairment: Dose reduction may be required.
Oral
Hookworm infections
Adult: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk.
Child: >1 yr: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk.
Hepatic impairment: Dose reduction may be required.
Oral
Enterobiasis
Adult: 100 mg as a single dose; may repeat if necessary 2-3 wk after initial treatment.
Child: >2 yr: 100 mg as a single dose; may repeat if necessary 2-3 wk after initial treatment.
Hepatic impairment: Dose reduction may be required.
Oral
Capillariasis
Adult: 200 mg bid for 20 days.
Child: >2 yr: 200 mg bid for 20 days.
Hepatic impairment: Dose reduction may be required.
Oral
Filariasis
Adult: Caused by Mansonella perstans: 100 mg bid for 30 days; caused by Onchocerca volvulus: 1 g bid for 28 days.
Child:
>2 yr: 100 mg bid for 30 days.
Hepatic impairment: Dose reduction may be required.
Oral
Toxocariasis
Adult: 100-200 mg bid for 5 days; may continue for up to 20 days.
Child: >2 yr: 100-200 mg bid for 5-20 days.
Hepatic impairment: Dose reduction may be required.
Oral
Trichinellosis
Adult: Caused by Trichinella spiralis
: 200-400 mg tid for 3 days followed by 400-500 mg tid for 10 days.
Child:
>2 yr: 200-400 mg tid for 3 days followed by 500 mg tid for 10 days.
Hepatic impairment: Dose reduction may be required.
Oral
Trichostrongyliasis
Adult: Caused by Trichostronglus
: 100 mg bid for 3 consecutive days.
Child:
>2 yr: 100 mg bid for 3 consecutive days.
Hepatic impairment: Dose reduction may be required.
Oral
Dracunculiasis
Adult: Caused by Dracunculus medinensis: 400-800 mg daily for 6 days.
Contraindications
Hypersensitivity. Infants and children <2 yr.
Warnings / Precautions
Monitor blood counts and hepatic function especially in patients receiving high doses. Pregnancy and lactation.
Adverse Reactions
Transient diarrhoea, abdominal pain, nausea, vomiting, headache, tinnitus, numbness, fever and dizziness.
Potentially Fatal: Myelosuppression (high doses).
Overdose Reactions
Symptoms: Abdominal pain, altered mental status. Management: Supportive.
Drug Interactions
Reduced plasma levels with enzyme inducers e.g. phenytoin, carbamazepine. Increased plasma levels with cimetidine.
See Below for More mebendazole Drug Interactions
Food Interactions
Fatty food increases absorption.
Mechanism of Actions
Mebendazole acts by destroying the cytoplasmic microtubules in the worm's intestinal cells. This blocks the uptake of glucose and other nutrients resulting in death of the helminth.
Absorption: Poorly absorbed from the GI tract.
Distribution: Highly protein-bound.
Metabolism: Extensively hepatic; undergoes 1st-pass elimination.
Excretion: Mainly via faeces (as unchanged drug and metabolites); via urine (2%, as unchanged drug and metabolites).
Administration
May be taken with or without food.
ATC Classification
P02CA01 - mebendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.
Available As
  • Mebendazole 100 mg
  • Mebendazole 150 mg
  • Mebendazole 200 mg
  • Mebendazole 500 mg
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