Magnesium

Indications
Oral
Dietary supplement
Adult: Adjust according to individual requirement. RDA (elemental magnesium): 19-30 yr: Female: 310 mg/day, pregnant female: 350 mg/day, male: 400 mg/day. ≥31 yr: Female: 320 mg/day, pregnant female: 360 mg/day, male: 420 mg/day.
Intravenous
Hypomagnesaemia
Adult: 4 g of Magnesium Chloride in 250 mL of 5% Dextrose inj given via IV infusion (Max rate: 3 mL/min). Monitor serum magnesium to guide subsequent dosage. Usual dosage range: 1-40 g Magnesium Chloride daily.
Contraindications
Intravenous: Patients with renal impairment, marked myocardial disease, and comatose condition.
Warnings / Precautions
Risk of hypermagnesaemia in patients with renal impairment. Caution in myasthenia gravis, pregnancy. Oral: Take with food to reduce stomach upset and diarrhoea. Intravenous: Administer cautiously if sweating and flushing occurs. Monitor serum magnesium concentrations, respiratory rate, blood pressure, deep tendon reflex and renal function.
Adverse Reactions
Oral: Watery diarrhoea, GI irritation. Intravenous: Nausea, vomiting, flushing, thirst, hypotension.
Potentially Fatal: Potentially Hazardous: Intravenous: Hypermagnesaemia may lead to respiratory depression, loss of deep tendon reflexes and cardiac arrest.
Overdose Reactions
Symptoms of hypermagnesaemia: Respiratory depression and loss of deep tendon reflexes due to neuromuscular blockade; nausea, vomiting, flushing, hypotension, drowsiness, bradycardia and muscle weakness. Treatment: In patients with normal renal function, IV fluids or furosemide may be given to promote Magnesium excretion. In patients with symptomatic hypermagnesaemia, slow IV inj of calcium gluconate can be used to antagonise the cardiac and neuromuscular effects of Magnesium.
Drug Interactions
Oral magnesium salts may decrease absorption of bisphosphonates, quinolone antibiotics and tetracycline derivatives; admin should be separated apart if concomitant use is required. Magnesium-containing products may reduce absorption of eltrombopag by 70%; separate admin by at least 4 hr. Calcitriol may increase serum concentrations of Magnesium salts. Magnesium salts may decrease serum concentrations of mycophenolate if used concurrently; monitor for reduced effects of mycophenolate. Concomitant use of trientine and magnesium salt may reduce serum concentrations of both agents.
See Below for More magnesium chloride Drug Interactions
Mechanism of Actions
Magnesium is essential to many enzymatic reactions in the body, acting as a cofactor in protein synthesis and carbohydrate metabolism. 8.36 g of Magnesium chloride (hexahydrate) is equivalent to about 1 g of magnesium. Each g of magnesium chloride (hexahydrate) represents about 4.9 mmol of magnesium and 9.8 mmol of chloride.
Absorption: Oral: About one-third is absorbed from the small intestine. The fraction of magnesium absorbed is inversely proportional to amount ingested.
Distribution: Plasma protein binding: About 25-30%. Magnesium crosses the placenta.
Excretion: Parenteral magnesium salts: Excreted mainly in urine. Oral magnesium salts: Via urine (absorbed fraction); faeces (unabsorbed fraction).
Storage Conditions
Intravenous: Oral: Store at room temperature, away from light and moisture. Intravenous inj: Prior to reconstitution, store at 15-30°C (59-86°F). Oral: Oral: Store at room temperature, away from light and moisture. Intravenous inj: Prior to reconstitution, store at 15-30°C (59-86°F).
ATC Classification
A12CC01 - magnesium chloride ; Belongs to the class of magnesium-containing preparations. Used as dietary supplements.
B05XA11 - magnesium chloride ; Belongs to the class of electrolyte solutions used in I.V. solutions.
Storage
Intravenous: Oral: Store at room temperature, away from light and moisture. Intravenous inj: Prior to reconstitution, store at 15-30°C (59-86°F). Oral: Oral: Store at room temperature, away from light and moisture. Intravenous inj: Prior to reconstitution, store at 15-30°C (59-86°F).
Available As
  • Magnesium 0.1 mg
  • Magnesium 0.33 mg
  • Magnesium 0.5 mg
  • Magnesium 0.6%
  • Magnesium 0.6% w/w
  • Magnesium 0.71 mg
  • Magnesium 0.8 mg
  • Magnesium 1 mg
  • Magnesium 1.1 mmol
  • Magnesium 1.14 gm
  • Magnesium 1.25 gm
  • Magnesium 1.4 mg
  • Magnesium 1.5 mg
  • Magnesium 1.8 mg
  • Magnesium 10 mg
  • Magnesium 100 mg
  • Magnesium 104 mg
  • Magnesium 104.19 mg
  • Magnesium 12 mg
  • Magnesium 12.5 mg
  • Magnesium 12.85 mg
  • Magnesium 120 mg
  • Magnesium 125 mg
  • Magnesium 140 mg
  • Magnesium 15 mg
  • Magnesium 150 mg
  • Magnesium 18 mg
  • Magnesium 18.75 mg
  • Magnesium 180 mg
  • Magnesium 185 mg
  • Magnesium 2 mg
  • Magnesium 2.5 mg
  • Magnesium 20 mg
  • Magnesium 200 mg
  • Magnesium 21.25 mg
  • Magnesium 216 mg
  • Magnesium 240 mg
  • Magnesium 25 mg
  • Magnesium 250 mg
  • Magnesium 27.51 mg
  • Magnesium 290 mg
  • Magnesium 3 meg
  • Magnesium 3 mg
  • Magnesium 3.2 mg
  • Magnesium 3.333 mg
  • Magnesium 30 mg
  • Magnesium 300 mg
  • Magnesium 30000 mcg
  • Magnesium 326.66 mg
  • Magnesium 33 mg
  • Magnesium 35 mg
  • Magnesium 375 mg
  • Magnesium 38 mg
  • Magnesium 4 mg
  • Magnesium 40 mg
  • Magnesium 400 mg
  • Magnesium 44 mg
  • Magnesium 45 mg
  • Magnesium 45.4 mg
  • Magnesium 47 mg
  • Magnesium 47.6 mg
  • Magnesium 5 mg
  • Magnesium 50 mg
  • Magnesium 500 mg
  • Magnesium 525 mg
  • Magnesium 53 mg
  • Magnesium 54 mg
  • Magnesium 54.49 mg
  • Magnesium 54.5 mg
  • Magnesium 54.9 mg
  • Magnesium 6 mg
  • Magnesium 60 mg
  • Magnesium 61 mg
  • Magnesium 65 mg
  • Magnesium 66.33 mg
  • Magnesium 72 mg
  • Magnesium 75 mg
  • Magnesium 8 meq
  • Magnesium 80 mg
  • Magnesium 88.9 mg
  • Magnesium 90 mg
  • Magnesium 91.8 mg
  • Magnesium 92 mg
  • Magnesium 94.4 mg
  • Magnesium 96 mg
  • Magnesium 98 mg
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    Magnesium Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Aglocid
    Aglowmed Ltd 1 Tablet
    ₹ 0.62
    10 Tablet
    ₹ 6.20
  • More Information Magnesium Hydroxide (Milk of Magnesia) 25 mg
  • More Information Aluminium Hydroxide 300 mg
  • More Information Simethicone 25 mg
  • More Information Magnesium Aluminium Silicate 50 mg
  • See Brands having above combination
    Gel Aglocid Gel (170 ml)
    Aglowmed Ltd 5 ml
    ₹ 0.91
    170 ml
    ₹ 31.00
  • More Information Dimethicone 25 mg
  • More Information Magnesium Hydroxide (Milk of Magnesia) 200 mg
  • More Information Aluminium Hydroxide 200 mg
  • See Brands having above combination
    Tablet Acirid (250+250)
    Modern Laboratories 1 Tablet
    ₹ 0.40
    10 Tablet
    ₹ 4.00
  • More Information Magnesium Hydroxide (Milk of Magnesia) 250 mg
  • More Information Aluminium Hydroxide 250 mg
  • See Brands having above combination
    Syrup Acinil (170 ml)
    Citadel Aurobindo Biotech Ltd. (CABL) 5 ml
    ₹ 0.52
    170 ml
    ₹ 17.75
  • More Information Dimethicone 50 mg
  • More Information Magnesium Hydroxide (Milk of Magnesia) 1.14 gm
  • More Information Aluminium Hydroxide 1.57 gm
  • See Brands having above combination
    Syrup Acinil O (120 ml)
    Citadel Aurobindo Biotech Ltd. (CABL) 5 ml
    ₹ 0.99
    120 ml
    ₹ 23.64
  • More Information Dimethicone 50 mg
  • More Information Oxethazine 10 mg
  • More Information Aluminium Hydroxide 1.567 gm
  • More Information Magnesium Hydroxide (Milk of Magnesia) 1.25 gm
  • See Brands having above combination
    Tablet Acidin MPS (250+250+50)
    East India Pharmaceutical Works Ltd. 1 Tablet
    ₹ 0.68
    8 Tablet
    ₹ 5.40
  • More Information Magnesium Hydroxide (Milk of Magnesia) 250 mg
  • More Information Dried Aluminium Hydroxide 250 mg
  • More Information Activated Dimethicone 50 mg
  • See Brands having above combination
    Tablet Acifix
    Morepen Laboratories Ltd. 1 Tablet
    ₹ 0.58
    10 Tablet
    ₹ 5.80
  • More Information Simethicone 50 mg
  • More Information Magnesium Hydroxide (Milk of Magnesia) 400 mg
  • More Information Dried Aluminium Hydroxide 200 mg
  • More Information Alginic Acid 100 mg
  • See Brands having above combination
    Suspension Acigel (200 ml)
    Ceza Formulations Pvt.Ltd 5 ml
    ₹ 0.85
    200 ml
    ₹ 34.00
  • More Information Magnesium Hydroxide (Milk of Magnesia) 250 mg
  • More Information Simethicone 50 mg
  • More Information Aluminium Hydroxide 250 mg
  • See Brands having above combination
    Suspension Acigon (150 ml)
    Sanofi Aventis 10 ml
    ₹ 0.92
    150 ml
    ₹ 13.80
  • More Information Magnesium Trisilicate 80 mg
  • More Information Sodium Bicarbonate 0.14 gm
  • More Information Dried Aluminium Hydroxide 0.16 gm
  • More Information Sodium Alginate 0.44 gm
  • See Brands having above combination
    Tablet Acigon CHW
    Sanofi Aventis 1 Tablet
    ₹ 0.33
    10 Tablet
    ₹ 3.25
  • More Information Magnesium Trisilicate 40 mg
  • More Information Sodium Bicarbonate 70 mg
  • More Information Dried Aluminium Hydroxide 80 mg
  • More Information Alginic Acid 200 mg
  • See Brands having above combination
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    Magnesium is used in following diseases

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    Drug - Drug Interactions of Magnesium
    Interaction
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Corticosteroids (Oral)
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Chloroquine
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Cefuroxime
    Minor, Monitor Therapy Magnesium carbonate, calcium carbonate, and folic acid vs Cefpodoxime
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Cefditoren
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Calcium Polystyrene Sulfonate
    Minor, Monitor Therapy Magnesium carbonate, calcium carbonate, and folic acid vs Calcium Channel Blockers
    Major, Avoid combination Magnesium carbonate, calcium carbonate, and folic acid vs Calcium Acetate
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Bisphosphonate Derivatives
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Bisphosphonate Derivatives
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