Indications |
Oral Acute bacterial exacerbation of chronic bronchitis Adult: 400 mg once daily for 10 days. Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
Oral Prophylaxis of surgical infections Adult: 400 mg as a single dose 1-6 hr before procedure. Oral Uncomplicated urinary tract infections Adult: 400 mg once daily. Due to E. coli: For 3 successive days. Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days. Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
Oral Complicated urinary tract infections Adult: Due to E. coli, K. pneumoniae, P. mirabilis or P. aeruginosa: 400 mg once daily for 14 successive days. Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
Ophthalmic Bacterial conjunctivitis Adult: Instil 0.3% solution into the affected eye/s. Otic/Aural Otitis externa Adult: Instil 0.3% solution into the affected ear/s. Otic/Aural Otitis media Adult: Instil 0.3% solution into the affected ear/s. Special Populations: Reduce dose in patients with moderate to severe renal impairment. CrCl: <40 mL/min: Initially, 400 mg. Maintenance: 200 mg daily. |
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Contraindications |
Hypersensitivity to the drug or other quinolones; children <18 yr; pregnancy and lactation. | ||||||||||||
Warnings / Precautions |
Avoid prolonged exposure to sunlight or artificial UV light. Known or suspected CNS disorders e.g. severe cerebral arteriosclerosis, epilepsy or other factors that predispose to seizures. Avoid in patients with known QT prolongation, uncorrected hypokalaemia. May impair ability to drive or operate machinery. Renal impairment. | ||||||||||||
Adverse Reactions |
Nausea, abdominal pain or discomfort, diarrhoea; headache, dizziness, insomnia; rash, pruritus, photosensitivity; thrombocytopenia. Potentially Fatal: Anaphylactic or anaphylactoid reactions. |
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Overdose Reactions |
Empty the stomach by inducing vomiting or by gastric lavage. Treatment is supportive. Maintain adequate hydration. Haemodialysis or peritoneal dialysis is unlikely to be helpful. | ||||||||||||
Drug Interactions |
Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid. Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents. See Below for More lomefloxacin Drug Interactions |
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Mechanism of Actions |
Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA. Absorption: Rapid and complete from the GI tract (oral); peak plasma concentrations after 1-1.5 hr. Absorption delayed with food. Distribution: Widely distributed; lungs and prostate. Protein-binding: 10%. Excretion: Via urine (as unchanged drug and small amounts of glucuronide metabolites); may be prolonged in renal impairment. Via faeces (small amounts as unchanged drug); 7-8 hr (elimination half-life). |
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Administration |
May be taken with or without food. |
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ATC Classification |
J01MA07 - lomefloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections. S01AX17 - lomefloxacin ; Belongs to the class of other antiinfectives. Used in the treatment of eye infections. |
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Available As |
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Lomefloxacin
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Lomefloxacin Containing Brands
Lomefloxacin is used in following diseases
Drug - Drug Interactions of Lomefloxacin
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