Lomefloxacin

Indications
Oral
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg once daily for 10 days.
Renal impairment: Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
CrCl (ml/min)Dosage Recommendation
10-40 Initially, 400 mg daily. Maintenance: 200 mg daily.

Oral
Prophylaxis of surgical infections
Adult: 400 mg as a single dose 1-6 hr before procedure.
Oral
Uncomplicated urinary tract infections
Adult: 400 mg once daily. Due to E. coli: For 3 successive days. Due to K. pneumoniae, P. mirabilis or S. saprophyticus: For 10 successive days.
Renal impairment:
Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
CrCl (ml/min)Dosage Recommendation
10-40Initially, 400 mg daily. Maintenance: 200 mg daily.

Oral
Complicated urinary tract infections
Adult: Due to E. coli, K. pneumoniae, P. mirabilis
or P. aeruginosa: 400 mg once daily for 14 successive days.
Renal impairment:
Haemodialysis: Initially, 400 mg daily. Maintenance: 200 mg daily.
CrCl (ml/min)Dosage Recommendation
10-40Initially, 400 mg daily. Maintenance: 200 mg daily.

Ophthalmic
Bacterial conjunctivitis
Adult: Instil 0.3% solution into the affected eye/s.
Otic/Aural
Otitis externa
Adult: Instil 0.3% solution into the affected ear/s.
Otic/Aural
Otitis media
Adult: Instil 0.3% solution into the affected ear/s.

Special Populations: Reduce dose in patients with moderate to severe renal impairment. CrCl: <40 mL/min: Initially, 400 mg. Maintenance: 200 mg daily.
Contraindications
Hypersensitivity to the drug or other quinolones; children <18 yr; pregnancy and lactation.
Warnings / Precautions
Avoid prolonged exposure to sunlight or artificial UV light. Known or suspected CNS disorders e.g. severe cerebral arteriosclerosis, epilepsy or other factors that predispose to seizures. Avoid in patients with known QT prolongation, uncorrected hypokalaemia. May impair ability to drive or operate machinery. Renal impairment.
Adverse Reactions
Nausea, abdominal pain or discomfort, diarrhoea; headache, dizziness, insomnia; rash, pruritus, photosensitivity; thrombocytopenia.
Potentially Fatal: Anaphylactic or anaphylactoid reactions.
Overdose Reactions
Empty the stomach by inducing vomiting or by gastric lavage. Treatment is supportive. Maintain adequate hydration. Haemodialysis or peritoneal dialysis is unlikely to be helpful.
Drug Interactions
Reduced bioavailability with sucralfate, antacids containing magnesium or aluminium, vitamin or mineral supplements containing iron. Increased serum levels with cimetidine. Potential increase in serum levels of ciclosporin. Renal elimination reduced with probenecid.
Potentially Fatal: Increased risk of ventricular arrhythmias with class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmic agents.
See Below for More lomefloxacin Drug Interactions
Mechanism of Actions
Lomefloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.
Absorption: Rapid and complete from the GI tract (oral); peak plasma concentrations after 1-1.5 hr. Absorption delayed with food.
Distribution: Widely distributed; lungs and prostate. Protein-binding: 10%.
Excretion: Via urine (as unchanged drug and small amounts of glucuronide metabolites); may be prolonged in renal impairment. Via faeces (small amounts as unchanged drug); 7-8 hr (elimination half-life).
Administration
May be taken with or without food.
ATC Classification
J01MA07 - lomefloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
S01AX17 - lomefloxacin ; Belongs to the class of other antiinfectives. Used in the treatment of eye infections.
Available As
  • Lomefloxacin 0.3%
  • Lomefloxacin 0.3% w/v
  • Lomefloxacin 3 mg
  • Lomefloxacin 400 mg
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