Lincomycin

Indications
Oral
Severe anaerobic infections
Adult: 500 mg 3 or 4 times daily.
Child: ≥1 mth: 30-60 mg/kg daily in divided doses.
Renal impairment: Severe impairment: Reduce to 25-30% of the usual dose.
Hepatic impairment: Dose adjustment may be needed.
Parenteral
Severe anaerobic infections
Adult: Dose can be administered by IM or IV inj. IM admin: 600 mg 1-2 times daily. IV admin: 0.6-1 g 2-3 times daily by slow IV infusion (over at least 1 hr), may increase up to a total of 8 g daily in severe infections.
Child: >1 mth: 10-20 mg/kg daily in divided doses by IM inj or IV infusion.
Renal impairment: Severe impairment: Reduce to 25-30% of the usual dose.
Hepatic impairment: Dose adjustment may be needed.
Subconjunctival
Severe anaerobic infections
Adult: Administer75 mg by subconjunctival inj to maintain sufficient MICs in the ocular fluid levels for at least 5 hr.
Renal impairment: Severe impairment: Reduce to 25-30% of the usual dose.
Hepatic impairment: Dose adjustment may be needed.

Special Populations: Reduce dose by 20-30% in patients with severe renal impairment.

Reconstitution: For IV admin: 1 g of lincomycin should be diluted in at least 100 ml of diluent.
Incompatibility: Syringe incompatibility: Ampicillin. Admixture incompatibility: Phenytoin, kanamycin.
Contraindications
Hypersensitivity to lincomycin or clindamycin.
Warnings / Precautions
Elderly. Severe renal and hepatic impairment. Pregnancy and lactation. Monitor liver function and CBC on long-term treatment. History of GI disease e.g. colitis.
Adverse Reactions
Hypotension (IV); vertigo; dermatitis, erythema multiforme, rash, urticaria; colitis, diarrhoea, glossitis, nausea, vomiting, pruritus ani, stomatitis; vaginitis; agranulocytosis, aplastic anaemia, leukopenia, neutropenia, pancytopenia, thrombocytopenic purpura; jaundice, LFT abnormalities; tinnitus; azotaemia, proteinuria, oliguria; hypersensitivity reactions.
Potentially Fatal: Anaphylaxis. IV: Syncope, CV collapse.
Drug Interactions
May potentiate effects of neuromuscular blocking agents. Reduced absorption with kaolin. May reduce effects of erythromycin.
See Below for More lincomycin Drug Interactions
Mechanism of Actions
Lincomycin exerts bacteriostatic and bactericidal effects by binding to 50S ribosome subunit. This results in inhibition of protein synthesis, specifically peptide-bond formation, in susceptible organisms.
Absorption: 20-30% is absorbed from the GI tract (oral); peak plasma concentrations after 2-4 hr. Food reduces rate and extent of absorption.
Distribution: Widely into tissues, bone, body fluids; CSF (poor, except when meninges are inflamed); crosses the placenta and enters breast milk.
Metabolism: Hepatic (partially inactivated).
Excretion: Via bile, urine, faeces (as unchanged drug and metabolites); 5 hr (elimination half-life).
Administration
Should be taken on an empty stomach. (Take w/ full glass of water on an empty stomach 1 hr before or 2 hr after meals.)
Storage Conditions
Oral: Store at 20-25°C. Parenteral: Store at 20-25°C. Subconjunctival: Store at 20-25°C.
ATC Classification
J01FF02 - lincomycin ; Belongs to the class of lincosamides. Used in the systemic treatment of infections.
Storage
Oral: Store at 20-25°C. Parenteral: Store at 20-25°C. Subconjunctival: Store at 20-25°C.
Available As
  • Lincomycin 125 mg
  • Lincomycin 2%
  • Lincomycin 2% w/w
  • Lincomycin 250 mg
  • Lincomycin 300 mg
  • Lincomycin 500 mg
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