Levosulpiride

Indications
Oral
Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia
Adult: 25 mg tid.
Elderly: Dose reductions may be necessary.

Special Populations: Lower initial doses have been recommended in elderly patients, subsequently adjusted as required. Dosage adjustment is also advised in patients with renal impairment.
Contraindications
Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.
Warnings / Precautions
May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido.
Potentially Fatal: Neuroleptic malignant syndrome.
Drug Interactions
Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.
See Below for More levosulpiride Drug Interactions
Mechanism of Actions
Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.
Absorption: Oral bioavailability is about 30%; peak plasma concentrations after about 3 hr.
Excretion: Mainly via urine. Plasma half-life: 9.7 hr (oral); 4.3 hr (IV).
Storage Conditions
Oral: Store at 15-30°C (59-86°F).
ATC Classification
N05AL07 - levosulpiride ; Belongs to the class of benzamides antipsychotics.
Storage
Oral: Store at 15-30°C (59-86°F).
Available As
  • Levosulpiride 100 mg
  • Sulpiride (Levosulpiride) 100 mg
  • Levosulpiride 12.5 mg
  • Sulpiride (Levosulpiride) 200 mg
  • Levosulpiride 25 mg
  • Sulpiride (Levosulpiride) 400 mg
  • Levosulpiride 50 mg
  • Levosulpiride 75 mg
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    One Response to Levosulpiride

    1. sandeep gurjar March 28, 2013 at 11:45 am #

      sir/madam
      i have completed m.pharma project on LEVOSULPIRIDE 75mg(sustain release tablets) .that reduse tid 25mg that admistrade only one time 75mg so is best reduse side effect…….
      thanks

      sandeep gurjar
      v.po tilawali teh. khetri jhunjhunu(rajasthan)

    Post Review about Levosulpiride

     


    Levosulpiride Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Lesu (25 mg) Vanran Healthcare Pvt Ltd 1 Tablet
    ₹ 5.70
    10 Tablet
    ₹ 57.00
  • More Information Levosulpiride 25 mg
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    Tablet Lesuride (25 mg) Sun Pharmaceutical Industries Ltd. 1 Tablet
    ₹ 5.70
    10 Tablet
    ₹ 57.00
  • More Information Levosulpiride 25 mg
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    Tablet Livogold (25 mg) Lupin Laboratories Ltd. 1 Tablet
    ₹ 5.30
    10 Tablet
    ₹ 53.00
  • More Information Levosulpiride 25 mg
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    Tablet Levogold (25 mg) Lupin Laboratories Ltd. 1 Tablet
    ₹ 5.30
    10 Tablet
    ₹ 53.00
  • More Information Levosulpiride 25 mg
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    Tablet Levazeo (25 mg) Torrent Pharmaceuticals Ltd. 1 Tablet
    ₹ 5.50
    10 Tablet
    ₹ 55.00
  • More Information Levosulpiride 25 mg
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    Tablet Neopride (25 mg) Intas Pharmaceuticals Ltd. 1 Tablet
    ₹ 4.17
    10 Tablet
    ₹ 41.73
  • More Information Levosulpiride 25 mg
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    Tablet Sertive (25 mg) Emcure Pharmaceuticals Ltd. 1 Tablet
    ₹ 5.50
    10 Tablet
    ₹ 55.00
  • More Information Levosulpiride 25 mg
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    Tablet Stride (100 mg) VGR Bio Laboratories 1 Tablet
    ₹ 3.30
    10 Tablet
    ₹ 33.00
  • More Information Sulpiride (Levosulpiride) 100 mg
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    Tablet Volapride (25 mg) Discovery (Mankind Pharmaceuticals Pvt. Ltd.) 1 Tablet
    ₹ 3.50
    10 Tablet
    ₹ 35.00
  • More Information Levosulpiride 25 mg
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    Tablet Zenpride (25 mg) Eris (Enzo Biopharma) 1 Tablet
    ₹ 5.50
    10 Tablet
    ₹ 55.00
  • More Information Levosulpiride 25 mg
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    Levosulpiride is used in following diseases

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    Drug - Drug Interactions of Levosulpiride

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