Levobunolol

Indications
 Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: As hydrochloride: 0.5% solution: 1-2 drops of in the affected eye(s) once daily; may be given bid for more severe or uncontrolled glaucoma. 0.25% solution: 1-2 drops bid.
Contraindications
 Bronchial asthma, severe COPD; sinus bradycardia; 2nd and 3rd degree heart block; overt cardiac failure; cardiogenic shock.
Warnings / Precautions
 Patients at risk of developing hypoglycaemia. DM. Thyrotoxicosis. Known diminished pulmonary function. Cerebrovascular insufficiency. Do not drive or operate machinery until vision is clear. Pregnancy and lactation.
Adverse Reactions
 Ocular stinging, burning, blepharoconjunctivitis, decreased heart rate, decreased BP, iridocyclitis, headache, transient ataxia, dizziness, lethargy, decreased corneal sensitivity, tearing, visual disturbances, urticaria and pruritus.
Drug Interactions
 Mydriasis may occur when used with epinephrine. Additive effects with catecholamine-depleting drugs e.g. reserpine. Possible AV conduction disturbances, LVF and hypotension with IV calcium antagonists. Additive prolongation of AV conduction time with digitalis and calcium antagonists. Additive hypotensive effects with phenothiazine-related agents. Additive effect with systemic β-blockers.
See Below for More levobunolol Drug Interactions
Mechanism of Actions
 Levobunolol, a nonselective β-adrenergic blocking agent, decreases IOP by reducing aqueous humour production.
Onset: Within 1 hr (ophthalmic).
Duration: Up to 24 hr (ophthalmic).
Absorption: Rapidly and almost completely absorbed from the GI trac t (oral).
Metabolism: Extensively hepatic.
Excretion: Via urine as metabolites and unchanged drug.
Storage Conditions
 Ophthalmic: Store at 15-30°C (59-86°F).
ATC Classification
 S01ED03 - levobunolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Storage
 Ophthalmic: Store at 15-30°C (59-86°F).
Available As
  • Levobunolol 0.5%
  • Levobunolol 5 mg

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