Levamisole

Indications
 Oral
Ascariasis
Adult: 150 mg as a single dose.
Child: 3 mg/kg as a single dose.
Oral
Mixed ascariasis hookworm infections
Adult: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.
Child: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.
Oral
Ancylostomiasis
Adult: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.
Child: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.
Contraindications
 Preexisting blood disorders; pregnancy and lactation; rheumatoid arthritis; severe renal impairment.
Warnings / Precautions
 Hepatic impairment, Sjogren's syndrome.
Adverse Reactions
 Nausea, vomiting, diarrhoea, abdominal pain, dizziness and headache. Fever, influenza-like syndrome, arthralgia, muscle pain, rash, taste disturbances and cutaneous vasculitis.
Potentially Fatal: Agranulocytosis, leucopenia, thrombocytopenia.
Drug Interactions
 May increase toxicity of phenytoin. Increases bioavailability of ivermectin; decreases bioavailability of albendazole. Alcohol causes disulfiram-like reaction.
See Below for More levamisole Drug Interactions
Mechanism of Actions
 Levamisole is the active laevo-isomer of tetramisole. It works by paralysing susceptible intestinal worms which are then excreted from the intestines. Levamisole also enhances cellular immune responses in humans.
Absorption: Well-absorbed from the GI tract. Peak plasma concentrations are achieved in 1.5-2 hr.
Metabolism: Occurs extensively in the liver.
Excretion: Mainly in the urine (70% as metabolites and 5% as unchanged drug) and small amounts in the faeces.
Administration
 Should be taken with food. (Take w/ meals to minimise side effects eg nausea.)
ATC Classification
 P02CE01 - levamisole ; Belongs to the class of imidazothiazole derivative agents. Used as antinematodal.
Available As
  • Levamisole 1.5% w/v
  • Levamisole 150 mg
  • Levamisole 30% w/w
  • Levamisole 40 mg
  • Levamisole 50 mg

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