Indications |
Oral Peripheral vascular disease Adult: 10-20 mg 3 or 4 times daily. Elderly: Initiate with lower doses. Parenteral To arrest premature labour Adult: 200-500 mcg/minute as IV infusion; adjust according to response until control is achieved. Monitor maternal BP and hydration, maternal and foetal heart rates during the infusion. Once labour has been arrested, administer 10 mg every 3-8 hr for several days via IM inj. May continue prophylaxis orally by giving 30-90 mg daily in divided doses. |
Contraindications |
Recent arterial haemorrhage. Do not give immediately postpartum and do not use in premature labour if there is an infection. |
Warnings / Precautions |
Pregnancy, lactation. |
Adverse Reactions |
Hypotension, dizziness, palpitation, nausea, vomiting, abdominal distress, severe rash, flushing, tachycardia. Maternal pulmonary oedema and foetal tachycardia (IV). |
Drug Interactions |
May potentiate effects of other vasodilators/hypotensive agents. See Below for More isoxsuprine Drug Interactions |
Mechanism of Actions |
Isoxsuprine is an α-receptor antagonist with β-receptor agonist action. It causes peripheral and cerebral vasodilatation by directly acting on vascular smooth muscle. It also causes cardiac and uterine relaxation. Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1 hr. Excretion: Via urine (as conjugates); 1.5 hr (elimination half-life). |
Administration |
May be taken with or without food. (May be taken w/ meals, milk or antacids to minimise GI discomfort.) |
Storage Conditions |
Oral: Store at room temperature, 15-30°C (59-86°F). Parenteral: Store at room temperature, 15-30°C (59-86°F). |
ATC Classification |
C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators. |
Storage |
Oral: Store at room temperature, 15-30°C (59-86°F). Parenteral: Store at room temperature, 15-30°C (59-86°F). |
Available As |
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Isoxsuprine
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Isoxsuprine Containing Brands
Isoxsuprine is used in following diseases
Drug - Drug Interactions of Isoxsuprine
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