Isoxsuprine

Indications
Oral
Peripheral vascular disease
Adult: 10-20 mg 3 or 4 times daily.
Elderly: Initiate with lower doses.
Parenteral
To arrest premature labour
Adult: 200-500 mcg/minute as IV infusion; adjust according to response until control is achieved. Monitor maternal BP and hydration, maternal and foetal heart rates during the infusion. Once labour has been arrested, administer 10 mg every 3-8 hr for several days via IM inj. May continue prophylaxis orally by giving 30-90 mg daily in divided doses.
Contraindications
Recent arterial haemorrhage. Do not give immediately postpartum and do not use in premature labour if there is an infection.
Warnings / Precautions
Pregnancy, lactation.
Adverse Reactions
Hypotension, dizziness, palpitation, nausea, vomiting, abdominal distress, severe rash, flushing, tachycardia. Maternal pulmonary oedema and foetal tachycardia (IV).
Drug Interactions
May potentiate effects of other vasodilators/hypotensive agents.
See Below for More isoxsuprine Drug Interactions
Mechanism of Actions
Isoxsuprine is an α-receptor antagonist with β-receptor agonist action. It causes peripheral and cerebral vasodilatation by directly acting on vascular smooth muscle. It also causes cardiac and uterine relaxation.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1 hr.
Excretion: Via urine (as conjugates); 1.5 hr (elimination half-life).
Administration
May be taken with or without food. (May be taken w/ meals, milk or antacids to minimise GI discomfort.)
Storage Conditions
Oral: Store at room temperature, 15-30°C (59-86°F). Parenteral: Store at room temperature, 15-30°C (59-86°F).
ATC Classification
C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.
Storage
Oral: Store at room temperature, 15-30°C (59-86°F). Parenteral: Store at room temperature, 15-30°C (59-86°F).
Available As
  • Isoxsuprine 10 mg
  • Isoxsuprine Hcl 10 mg
  • Isoxsuprine 20 mg
  • Isoxsuprine Hcl 20 mg
  • Isoxsuprine 40 mg
  • Isoxsuprine Hcl 40 mg
  • Isoxsuprine Hcl IP 40 mg
  • Isoxsuprine Hcl 5 mg
  • Isoxsuprine 5 mg
  • Isoxsuprine 50 mg
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