Indications |
Subcutaneous Diabetes mellitus Adult: According to requirements; administer once daily at the same time each day. For insulin-naive patients: May initiate with 10 IU once daily. Adjust subsequently based on response to achieve glycaemic targets. Usual range: 2-100 IU/day. Child: ≥6 yr: According to requirements; administer once daily at the same time each day. Renal impairment: Decreased dose may be necessary. Hepatic impairment: Decreased dose may be necessary. Special Populations: Renal impairment: CrCl 10-50 mL/min: 75% of normal dose; <10 mL/min: 25-50% of normal dose and monitor glucose closely. |
Contraindications |
Hypoglycaemia; IV route. |
Warnings / Precautions |
Renal or hepatic impairment; pregnancy; lactation; child <6 yrs. Transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections; hypokalaemia. |
Adverse Reactions |
Hypoglycaemia; oedema; pruritus; rash; hypersensitivity reactions; lipoatrophy or lipohypertrophy with SC Inj (rotate Inj site). |
Drug Interactions |
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g. octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by β-blockers, clonidine. See Below for More insulin glargine Drug Interactions |
Mechanism of Actions |
Insulin glargine, a long-acting analog of human insulin, regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal. Onset: 1 hr Duration: 24 hrs. |
ATC Classification |
A10AE04 - insulin glargine ; Belongs to the class of long-acting insulins and analogues for injection. Used in the treatment of diabetes. |
Available As |
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Insulin (Analogue) Glargine
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Insulin (Analogue) Glargine Containing Brands
Insulin (Analogue) Glargine is used in following diseases
Drug - Drug Interactions of Insulin (Analogue) Glargine
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