Insulin (Analogue) Glargine

Indications
Subcutaneous
Diabetes mellitus
Adult: According to requirements; administer once daily at the same time each day. For insulin-naive patients: May initiate with 10 IU once daily. Adjust subsequently based on response to achieve glycaemic targets. Usual range: 2-100 IU/day.
Child: ≥6 yr: According to requirements; administer once daily at the same time each day.
Renal impairment: Decreased dose may be necessary.
Hepatic impairment: Decreased dose may be necessary.

Special Populations: Renal impairment: CrCl 10-50 mL/min: 75% of normal dose; <10 mL/min: 25-50% of normal dose and monitor glucose closely.
Contraindications
Hypoglycaemia; IV route.
Warnings / Precautions
Renal or hepatic impairment; pregnancy; lactation; child <6 yrs. Transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections; hypokalaemia.
Adverse Reactions
Hypoglycaemia; oedema; pruritus; rash; hypersensitivity reactions; lipoatrophy or lipohypertrophy with SC Inj (rotate Inj site).
Drug Interactions
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g. octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by β-blockers, clonidine.
See Below for More insulin glargine Drug Interactions
Mechanism of Actions
Insulin glargine, a long-acting analog of human insulin, regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Onset: 1 hr
Duration: 24 hrs.
ATC Classification
A10AE04 - insulin glargine ; Belongs to the class of long-acting insulins and analogues for injection. Used in the treatment of diabetes.
Available As
  • Insulin (Analogue) Glargine 100 iu
  • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Insulin (Analogue) Glargine


    Insulin (Analogue) Glargine Containing Brands

    We are Developing Our database, More results coming soon.

    Insulin (Analogue) Glargine is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Insulin (Analogue) Glargine

    We are Developing Our database, More results coming soon.