Indications |
Subcutaneous Diabetes mellitus Adult: Administer 5-10 min before meal. Usual range: 0.5-1 units/kg/day. When used in a meal-related SC inj treatment regimen, insulin aspart may provide 50-70% of total insulin requirement with the remainder provided by an intermediate-acting or long-acting insulin. Renal impairment: Decreased dose may be necessary. Hepatic impairment: Decreased dose may be necessary. Special Populations: Renal impairment: CrCl 10-50 mL/min: 75% of normal dose; <10 mL/min: 25-50% of normal dose and monitor glucose closely. |
Contraindications |
Hypoglycaemia |
Warnings / Precautions |
Renal or hepatic impairment; pregnancy; lactation. Transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections; hypokalaemia. |
Adverse Reactions |
Hypoglycaemia; oedema; pruritus; rash; hypersensitivity reactions; lipoatrophy or lipohypertrophy with SC Inj (rotate Inj site). |
Drug Interactions |
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by β-blockers, clonidine. See Below for More insulin aspart Drug Interactions |
Mechanism of Actions |
Insulin aspart, a rapid-acting analog of human insulin, lowers blood glucose levels; it regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal. Onset: 0.5 hr. Duration: 3-5 hrs. |
Administration |
Should be taken with food. (Administer immediately before a meal.) |
ATC Classification |
A10AB05 - insulin aspart ; Belongs to the class of fast-acting insulins and analogues. Used in the treatment of diabetes. A10AD05 - insulin aspart ; Belongs to the class of intermediate-acting combined with fast-acting insulins and analogues. Used in the treatment of diabetes. |
Available As |
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Insulin (Analogue) Aspart
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Insulin (Analogue) Aspart Containing Brands
Insulin (Analogue) Aspart is used in following diseases
Drug - Drug Interactions of Insulin (Analogue) Aspart
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