Insulin (Analogue) Aspart

Indications
Subcutaneous
Diabetes mellitus
Adult: Administer 5-10 min before meal. Usual range: 0.5-1 units/kg/day. When used in a meal-related SC inj treatment regimen, insulin aspart may provide 50-70% of total insulin requirement with the remainder provided by an intermediate-acting or long-acting insulin.
Renal impairment: Decreased dose may be necessary.
Hepatic impairment: Decreased dose may be necessary.

Special Populations: Renal impairment: CrCl 10-50 mL/min: 75% of normal dose; <10 mL/min: 25-50% of normal dose and monitor glucose closely.
Contraindications
Hypoglycaemia
Warnings / Precautions
Renal or hepatic impairment; pregnancy; lactation. Transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections; hypokalaemia.
Adverse Reactions
Hypoglycaemia; oedema; pruritus; rash; hypersensitivity reactions; lipoatrophy or lipohypertrophy with SC Inj (rotate Inj site).
Drug Interactions
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by β-blockers, clonidine.
See Below for More insulin aspart Drug Interactions
Mechanism of Actions
Insulin aspart, a rapid-acting analog of human insulin, lowers blood glucose levels; it regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Onset: 0.5 hr.
Duration: 3-5 hrs.
Administration
Should be taken with food. (Administer immediately before a meal.)
ATC Classification
A10AB05 - insulin aspart ; Belongs to the class of fast-acting insulins and analogues. Used in the treatment of diabetes.
A10AD05 - insulin aspart ; Belongs to the class of intermediate-acting combined with fast-acting insulins and analogues. Used in the treatment of diabetes.
Available As
  • Insulin (Analogue) Aspart 100 iu
  • Insulin (Analogue) Aspart 30%/100 iu
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