Indapamide

Indications
 Oral
Hypertension
Adult: 1.25-2.5 mg once daily, alone or in conjunction with other antihypertensives.
Oral
Oedema
Adult: 2.5 mg once daily increased to 5 mg daily after 1 wk if needed.
Contraindications
 Anuria, severe hepatic impairment.
Warnings / Precautions
 Pregnancy, lactation, elderly, renal impairment, fluid or electrolyte imbalance, hyperuricaemia, DM, lupus erythematosus.
Adverse Reactions
 Headache, dizziness, weakness, drowsiness, fatigue, agitation, nervousness, anorexia, nausea, vomiting, pain, diarrhoea, constipation, orthostatic hypotension, palpitations, hypokalaemia, hyponatraemia, metabolic alkalosis.
Overdose Reactions
 Nausea, vomiting, weakness, GI disorders, electrolyte imbalance. In severe cases, hypotension and respiratory depression. Stomach emptying recommended.
Drug Interactions
 Additive effect with other antihypertensive agents and diuretics. Increased chance of hypokalaemia with corticosteroids, corticotropin and amphotericin.
Potentially Fatal: Increased risk of lithium toxicity. Hypokalaemia enhances digitalis toxicity with cardiac gycosides.
See Below for More indapamide Drug Interactions
Mechanism of Actions
 Indapamide enhances excretion of sodium, chloride and water by interfering with the transport of sodium ions across the renal tubular epithelium.
Absorption: Rapidly and completely absorbed from the GI tract (oral). Peak plasma levels are achieved within 2-2.5 hr.
Distribution: Widely distributed, preferentially and reversibly bound to erythrocytes.
Metabolism: Extensively metabolised in the liver.
Excretion: Via urine (60-70% as metabolites, 5-7% as unchanged), via faeces (16-23% remaining dose); 14 hr (elimination half-life).
Administration
 Should be taken with food.
Storage Conditions
 Oral: Store at 20-25°C.
ATC Classification
 C03BA11 - indapamide ; Belongs to the class of low-ceiling sulfonamide diuretics.
Storage
 Oral: Store at 20-25°C.
Available As
  • Indapamide 0.625 mg
  • Indapamide 1.25 mg
  • Indapamide 1.5 mg
  • Indapamide 2.5 mg
  • Indapamide 3 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Indapamide


    Indapamide Containing Brands

    We are Developing Our database, More results coming soon.

    Indapamide is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Indapamide

    We are Developing Our database, More results coming soon.