Hydroquinone

Indications	Topical/Cutaneous Hyperpigmentated skin conditions *Adult:* Apply and rub in a thin layer of 2-4% preparation to affected area bid.
Contraindications	Hypersensitivity. Sunburn or depilatory usage. Children <12 yr.
Warnings / Precautions	Pregnancy, lactation. Avoid contact with eyes and on abraded or sunburnt skin. Avoid unnecessary exposure to sunlight. Limit application to area no larger than face and neck or hands and arms. Not advised to use when itching, vesicle formation, or excessive inflammation occurs. Discontinue application if there is no improvement after 2 mth of treatment.
Adverse Reactions	Transient erythema, mild burning sensations; hyperpigmentation. Staining and corneal opacities. Tremors and convulsions after systemic absorption. Occasionally, hypersensitivity.
Overdose Reactions	Tremors, seizures, and occasionally severe hemolytic anemia. Administration of activated charcoal and gastric lavage, followed by supportive therapy.
Mechanism of Actions	Hydroquinone is a topical depigmentating agent used in hyperpigmentation conditions by suppressing melanocyte metabolic processes. It also increases melanin excretion from melanocytes and prevents its production.
ATC Classification	D11AX11 - hydroquinone ; Belongs to the class of other dermatologicals.
Available As	Hydroquinone 2% Hydroquinone 2% w/w Hydroquinone 2.00% Hydroquinone 3% Hydroquinone 4% Hydroquinone 4% w/w Hydroquinone 5% Hydroquinone 5% w/v Hydroquinone 5% w/w

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