Indications |
Oral Dermatophytosis Adult: 0.5-1 g daily in single or divided doses for 2-8 wk in hair and skin infections, 6 mth in fingernail infections and 12 mth or more for toenail infections. Child: 10 mg/kg daily. |
Contraindications |
Severe liver disease; porphyria; monilial infection; SLE; pregnancy. |
Warnings / Precautions |
Lactation; may impair ability to drive or operate machinery; avoid exposure to intense sunlight or artificial light. Regular monitoring of the renal, hepatic and blood tests should be done. |
Adverse Reactions |
Oral thrush; GI distress, taste perversion; dizziness, confusion, headache, depression, insomnia, fatigue; peripheral neuritis, photosensitivity; skin rashes, urticaria, erythema multiforme; leucopenia, proteinuria. Potentially Fatal: Hepatotoxicity; angioedema. |
Drug Interactions |
Antagonises oral anticoagulants and oral contraceptives. Decreased GI absorption with phenobarbital. Reduced plasma concentrations with enzyme inducers e.g. phenylbutazone and hypnotics. Potentially Fatal: Enhances effects of alcohol and causes disulfiram-like reaction. See Below for More griseofulvin Drug Interactions |
Food Interactions |
High-fat meal enhances absorption. |
Mechanism of Actions |
Griseofulvin is a fungistatic antibiotic that inhibits fungal cell division at metaphase and binds to human keratin making it resistant to fungal infections. It has activity against common dermatophytes including epidermophyton, Microsporum, or Trichophyton spp. Absorption: Variably and incompletely absorbed from the GI tract (oral), may be increased by decreasing particle size and admin with fatty meals; peak plasma concentrations after 4 hrs. Distribution: Keratin precursor cells, stratum corneum of the skin and nails. Protein-binding: 84%. Metabolism: Hepatic; conveted to 6-demethylgriseofulvin and few glucuronide conjugates. Excretion: Via urine (<1% as unchanged; 6-demethylgriseofulvin, and glucuronide conjugates), via faeces (large amount of reduced particle size), via sweat; 9-24 hr (elimination half-life). |
Administration |
Should be taken with food. (Take immediately after meals.) |
Storage Conditions |
Oral: Store at 15-30°C. |
ATC Classification |
D01AA08 - griseofulvin ; Belongs to the class of antibiotics. Used in the topical treatment of fungal infection. D01BA01 - griseofulvin ; Belongs to the class of antifungals for systemic use. |
Storage |
Oral: Store at 15-30°C. |
Available As |
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Griseofulvin
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Griseofulvin Containing Brands
Griseofulvin is used in following diseases
Drug - Drug Interactions of Griseofulvin
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