Gemifloxacin

Indications
 Oral
Acute bacterial exacerbation of chronic bronchitis
Adult: 320 mg once daily for 5 days.
CrCl (ml/min)Dosage Recommendation
≤40160 mg every 24 hr.

Oral
Community-acquired pneumonia
Adult: 320 mg once daily for 7 days.
CrCl (ml/min)Dosage Recommendation
≤40160 mg every 24 hr.


Special Populations: Renal insufficiency: No dosage adjustment is required in patients with CrCl >40 mL/min. Dosage should be halved in patients with CrCl under 40 mL/min and those receiving haemodialysis or continuous peritoneal dialysis.
Contraindications
 Hypersensitivity. Patients receiving class IA or III antiarrhythmics.
Warnings / Precautions
 History of prolongation of QT interval, uncorrected electrolyte disorders, CNS diseases such as epilepsy. Maintain adequate hydration. Increased risk of rash when treatment duration is prolonged. Children <18 yr. Pregnancy, lactation.
Adverse Reactions
 Diarrhoea, nausea, vomiting; headache, dizziness; rash, urticaria. May cause elevation of liver enzymes.
Overdose Reactions
 Treatment is symptomatic. Stomach may be emptied by inducing vomiting or gastric lavage.
Drug Interactions
 Lower bioavailability if coadministered with multivalent cation preparations e.g. aluminum, magnesium, or iron salts. May potentiate QT prolongation when used with drugs that affect the QT interval e.g. cisapride, erythromycin, antipsychotics and TCAs. May increase prothrombin time when used with warfarin or its derivatives. Increased plasma levels when used with probenecid.
See Below for More gemifloxacin Drug Interactions
Mechanism of Actions
 Gemifloxacin inhibits DNA gyrase and DNA topoisomerase IV. DNA gyrase is needed for DNA replication and transcription, DNA repair, recombination and transposition. Topoisomerase IV facilitates separation of intertwined, replicated DNA before cell division occurs. Gemifloxacin forms a ternary complex with gyrase and topoisomerase IV, which blocks DNA replication, thus resulting in DNA release, chromosomal disruption and cell death.
Absorption: Rapidly absorbed from the GI tract; absolute bioavailability: About 71%.
Distribution: Widely distributed into body tissues including bronchial mucosa and lungs. 55-73% bound to plasma proteins.
Metabolism: Limited hepatic metabolism.
Excretion: Elimination half-life: 7 hr. As unchanged drug and metabolites in the faeces and urine.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store between 15-30°C.
ATC Classification
 J01MA15 - gemifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Storage
 Oral: Store between 15-30°C.
Available As
  • Gemifloxacin 320 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Gemifloxacin


    Gemifloxacin Containing Brands

    We are Developing Our database, More results coming soon.

    Gemifloxacin is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Gemifloxacin

    We are Developing Our database, More results coming soon.