Flutamide

Indications
 Oral
Palliative treatment of prostatic carcinoma
Adult: 250 mg tid preferably at least 3 days before gonadorelin analogue treatment.
Contraindications
 Hypersensitivity, severe hepatic impairment, pregnancy and lactation.
Warnings / Precautions
 Perform liver function tests before starting treatment and at regular intervals. Treatment is not recommended in patients whose ALT values exceed twice the upper limit of normal. Regular assessment of prostate specific antigen level may help to monitor disease progression. Advise patient against discontinuing drug on their own. Exercise caution in patients with cardiac disease.
Adverse Reactions
 Hot flushes, loss of libido, impotence, gynaecomastia, nausea, vomiting, diarrhoea, increased appetite, sleep disturbances, skin reactions, anaemias, headache, dizziness, malaise, anxiety, hypertension, gastric and chest pain, oedema, blurred vision, hepatitis, jaundice, rash, thirst, pruritus, SLE-like syndrome, drowsiness, confusion, depression, nervousness.
Drug Interactions
 Increased prothrombin time in patients on long-term warfarin treatment.
See Below for More flutamide Drug Interactions
Mechanism of Actions
 Flutamide is a nonsteroidal 'pure' antiandrogen which acts directly on the target tissues either by blocking androgen uptake or by inhibiting cytoplasmic and nuclear binding of androgen.
Distribution: Protein-binding: 90%
Metabolism: Rapid and extensive; converted to hydroxyflutamide.
Excretion: Urine, faeces (small amounts); 2 hrs (elimination half-life, metabolite).
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 L02BB01 - flutamide ; Belongs to the class of anti-androgens.
Storage
 Oral: Store at 25°C.
Available As
  • Flutamide 250 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Flutamide


    Flutamide Containing Brands

    We are Developing Our database, More results coming soon.

    Flutamide is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Flutamide

    We are Developing Our database, More results coming soon.