Indications |
Oral Seasonal allergic rhinitis Adult: 120 mg once daily. Child: 6-11 yr: 30 mg bid. Renal impairment: Adult: Initially, 60 mg once daily. Child: 6 mth-<2 yr: 15 mg once daily and 2-11 yr: 30 mg once daily. Oral Chronic idiopathic urticaria Adult: 180 mg once daily. Child: 6 mth-<2 yr: 15 mg bid; ≥2 yr: 30 mg bid. Renal impairment: Adult: Initially, 60 mg once daily. Child: 6 mth-<2 yr: 15 mg once daily and 2-11 yr: 30 mg once daily. Special Populations: In patients with decreased renal function: 60 mg once daily. |
Contraindications |
Hypersensitivity. |
Warnings / Precautions |
Renal impairment. Pregnancy, lactation; children <6 yr. |
Adverse Reactions |
Viral infection (cold/flu); headache, dizziness, drowsiness, fatigue; nausea, dyspepsia, dysmenorrhoea. |
Drug Interactions |
Co-admin with ketoconazole or erythromycin may increase plasma levels of fexofenadine. May increase adverse effects of other anticholinergics and CNS depressants. May increase arrhythmogenic effect of antipsychotic agents (phenothiazines); avoid concurrent usage. May reduce the efficacy of betahistine. Pramlintide may increase the anticholinergic effect of fexofenadine. Bioavailability may be increased by verapamil. Efficacy may be reduced by rifampin. See Below for More fexofenadine Drug Interactions |
Food Interactions |
Decreased levels with St John's wort. Fruit juice (apple, grapefruit, orange) may reduce bioavailability of fexofenadine by about 36%. Possible increased risk of sedation with ethanol. |
Mechanism of Actions |
Fexofenadine, an active metabolite of terfenadine, is a competitive peripheral histamine H1-receptor antagonist on effector cells in the GI tract, blood vessels and respiratory tract. Absorption: Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 2-3 hr. Distribution: Enters breast milk. 60-70% bound to plasma proteins. Metabolism: Intestinal mucosa (5% of total dose); hepatic (0.5-1.5% of dose). Excretion: Mainly via faeces, via urine (10% of dose); 14 hr (elimination half-life; may be prolonged in renal impairment). |
Administration |
Should be taken on an empty stomach. (Take before meals. Do not take w/ fruit juice. ) |
Storage Conditions |
Oral: Store at 20-25°C. |
ATC Classification |
R06AX26 - fexofenadine ; Belongs to the class of other antihistamines for systemic use. |
Storage |
Oral: Store at 20-25°C. |
Available As |
|
Fexofenadine
Post Review about Fexofenadine Click here to cancel reply.
Fexofenadine Containing Brands
Fexofenadine is used in following diseases
Drug - Drug Interactions of Fexofenadine
Latest News
- FDA approves Ruconest for treatment of hereditary angioedema
- FDA recommend against aspirin to prevent First Heart Attacks
- FDA approves Pomalyst (pomalidomide) for advanced multiple myeloma
- FDA approves three new drug treatments for type 2 diabetes
- Long-term consequences of vaginal delivery on the pelvic floor
No comments yet.