Etoricoxib

Indications
 Oral
Osteoarthritis
Adult: 60 mg once daily.
Hepatic impairment: Mild impairment (Child-Pugh score of 5 or 6): 60 mg once daily; moderate impairment (Child-Pugh 7-9): 60 mg every other day. Avoid in severe hepatic impairment (Child-Pugh ≥10).
Oral
Rheumatoid arthritis
Adult: 90 mg once daily.
Hepatic impairment: Mild impairment (Child-Pugh score of 5 or 6): 60 mg once daily; moderate impairment (Child-Pugh 7-9): 60 mg every other day. Avoid in severe hepatic impairment (Child-Pugh ≥10).
Oral
Acute gout
Adult: 120 mg once daily. Max duration: 8 days.
Hepatic impairment: Mild impairment (Child-Pugh score of 5 or 6): 60 mg once daily; moderate impairment (Child-Pugh 7-9): 60 mg every other day. Avoid in severe hepatic impairment (Child-Pugh ≥10).

Special Populations: Patients with mild hepatic impairment: 60 mg once daily. Moderate hepatic impairment: 60 mg every other day.
Contraindications
 Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr.
Warnings / Precautions
 Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.
Adverse Reactions
 GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity.
Drug Interactions
 CYP3A4 inhibitors or inducers; rifampicin, ethinyloestradiol; oral salbutamol and minoxidil. Antidepressant SSRIs and venlafaxine may increase risk of bleeding. Risk of side effects increased with concomitant use of aspirin, ciclosporin, ketorolac or other NSAIDs. Lithium and methotrexate, coumarins, phenindione, phenytoin and sulphonylureas.
See Below for More etoricoxib Drug Interactions
Mechanism of Actions
 Etoricoxib selectively inhibits cyclooxygenase 2 (COX-2).
Administration
 May be taken with or without food.
ATC Classification
 M01AH05 - etoricoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.
Available As
  • Etoricoxib 120 mg
  • Etoricoxib 25 mg
  • Etoricoxib 60 mg
  • Etoricoxib 90 mg

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