Econazole

Indications
 Topical/Cutaneous
Skin fungal infections
Adult: Apply 1% cream, lotion, powd or soln up to tid. Continue for 2-4 wk.
Child: Same as adult dose.
Topical/Cutaneous
Nail fungal infections
Adult: As 1% cream/lotion: Apply once daily under occlusive dressing.
Vaginal
Vaginal candidiasis
Adult: 150 mg pessaries once daily at bedtime for 3 consecutive nights or a single dose of 150 mg (as a long-acting formulation). Alternatively, 5 g of 10% cream every night for 2 wk.
Contraindications
 Hypersensitivity. Porphyria; pregnancy.
Warnings / Precautions
 Avoid contact with eyes and mucous membranes. May damage latex contraceptives. Pregnancy.
Adverse Reactions
 Vulvar/vaginal burning; burning sensation; erythema; itching; contact dermatitis.
Mechanism of Actions
 Econazole modifies the permeability of cell wall membrane in fungi; may interfere with RNA and protein synthesis, and lipid metabolism.
Absorption: Insignificant (topical or vaginal).
Storage Conditions
 Topical/Cutaneous: Store below 30°C. Vaginal: Store below 30°C.
ATC Classification
 D01AC03 - econazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
G01AF05 - econazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.
Storage
 Topical/Cutaneous: Store below 30°C. Vaginal: Store below 30°C.
Available As
  • Econazole Nitrate 1%
  • Econazole 1%
  • Econazole Nitrate 1% w/w
  • Econazole Nitrate 10 mg
  • Econazole Nitrate 150 mg

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