Dutasteride

Indications
 Oral
Benign prostatic hyperplasia
Adult: 500 mcg daily (treatment for 6 mth may be required before benefit is obtained).
Contraindications
 Severe liver impairment; pregnant women, children, adolescent.
Warnings / Precautions
 Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling dutasteride capsules. Advisable to exclude other causes of benign prostatic hypertrophy (e.g. prostate cancer, infection) before initiating therapy.
Adverse Reactions
 Impotence; decreased libido; ejaculation disorders; breast tenderness and enlargement.
Overdose Reactions
 Treatment is symptomatic and supportive.
Drug Interactions
 Concurrent use with CYP3A4 inhibitors such as diltiazem and verapamil may increase serum levels of dutasteride.
See Below for More dutasteride Drug Interactions
Lab Interactions
 May interfere with interpretation of prostate-specific antigen test results.
Mechanism of Actions
 Dutasteride has antiandrogenic properties. It inhibits 5α-reductase, thus preventing the conversion of testosterone to 5α-dihydrotestosterone which is the main androgen involved in causing prostate enlargement.
Absorption: Absorbed from the GI tract, reaching peak serum concentration in 1-3 hr. Bioavailability: About 60%.
Distribution: Highly bound to plasma proteins.
Metabolism: Metabolised by CYP3A4 and CYP3A5.
Excretion: Mainly excreted as metabolites in faeces. Elimination half-life: About 3-5 wk.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 G04CB02 - dutasteride ; Belongs to the class of testosterone-5-alpha reductase inhibitors. Used in the treatment of benign prostatic hypertrophy.
Storage
 Oral: Store at 25°C.
Available As
  • Dutasteride 0.5 mg

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