Drotaverine

Indications
 Oral
Antispasmodic
Adult: 40-80 mg tid.
Child: 1-6 yr: 20 mg 3-4 times daiily; >6 yr: 40 mg tid.
Contraindications
 Severe renal/hepatic/cardiac dysfunction. Porphyria.
Warnings / Precautions
 Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.
Adverse Reactions
 Vertigo, nausea, vomiting, dry mouth.
Drug Interactions
 May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.
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Mechanism of Actions
 Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
Administration
 May be taken with or without food.
ATC Classification
 A03AD02 - drotaverine ; Belongs to the class of papaverine and derivatives. Used in the treatment of functional bowel disorders.
Available As
  • Drotaverine 10 mg
  • Drotaverine 20 mg
  • Drotaverine 40 mg
  • Drotaverine 50 mg
  • Drotaverine 60 mg
  • Drotaverine 80 mg

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