Indications |
Oral Depression Adult: Initially, 25 mg tid, gradually increased to 50 mg tid if necessary, alternatively as a single dose at night. Up to 225 mg/day may be used in severe depression. Elderly: Initially, 50-75 mg daily. |
Contraindications |
Hypersensitivity, recent MI, neonates, heart block, cardiac arrhythmias, mania, alcohol, other CNS depressants, severe liver disease, prostate disease, children. |
Warnings / Precautions |
Epilepsy, hypertension, glaucoma, urinary retention, gradual withdrawal, pregnancy, lactation, elderly. |
Adverse Reactions |
Cholestatic jaundice, sexual dysfunction, exacerbation of psychotic manifestation, cardiac arrhythmias, hypotension, dry mouth, constipation, disturbance of accommodation, tachycardia, postural hypotension, drowsiness, tremors and skin rash. Withdrawal symptoms with abrupt cessation: Insomnia, irritability and excessive sweating. Potentially Fatal: Bone marrow depression, cardiac arrhythmias and agranulocytosis, reports of ventricular fibrillation and renal failure. |
Drug Interactions |
Barbiturates reduce antidepressant effect of dosulepin. Raised serum concentrations with methylphenidate. Cigarette smoking enhances metabolism. Increased risk of ventricular arrhythmias when used with drugs that prolong QT interval. Potentially Fatal: Should not be given concurrently or within 14 days of stopping MAOIs. Potentiates catecholamines, sympathomimetics, narcotics and alcohol. Reduces hypotensive activity of bethanidine, guanethidine. See Below for More dosulepin Drug Interactions |
Mechanism of Actions |
Also known as dothiepin. It inhibits the neuronal re-uptake of noradrenaline in the CNS. Its antidepressant activity appears to be related with inhibition of monoamine neurotransmitter re-uptake. Absorption: Readily absorbed from the GI tract (oral). Distribution: Enters breast milk. Metabolism: Extensively hepatic via demethylation to desmethyldothiepin, S-oxidation. Excretion: Urine (as metabolites), faeces (small amounts). Elimination half-life: 14-24 hr (dosulepin), 23-46 hr (metabolites). |
ATC Classification |
N06AA16 - dosulepin ; Belongs to the class of non-selective monoamine reuptake inhibitors. Used in the management of depression. |
Available As |
|
Dothiepin (Dosulepin)
Post Review about Dothiepin (Dosulepin) Click here to cancel reply.
Dothiepin (Dosulepin) Containing Brands
Dothiepin (Dosulepin) is used in following diseases
Drug - Drug Interactions of Dothiepin (Dosulepin)
Latest News
- FDA approves Ruconest for treatment of hereditary angioedema
- FDA recommend against aspirin to prevent First Heart Attacks
- FDA approves Pomalyst (pomalidomide) for advanced multiple myeloma
- FDA approves three new drug treatments for type 2 diabetes
- Long-term consequences of vaginal delivery on the pelvic floor
No comments yet.