Docusate

Indications
 Oral
Constipation
Adult: 50-500 mg/day in 1-4 divided doses.
Child: 6-12 yr: 40-120 mg/day; 3-6 yr: 20-60 mg/day. To be given in 1-4 divided doses.
Otic/Aural
Ceruminolytic
Adult: As 0.5 % ear drops: Administer sufficient soln to fill the affected ear(s) on not more than 2 consecutive nights, before syringing if needed.
Rectal
Constipation
Adult: Per 10 g enema gel contains 0.12 g docusate sodium: Use 1 enema; 2nd enema may be used on the same day or the next day as needed.
Contraindications
 Intestinal obstruction or undiagnosed abdominal symptoms. Prolonged use. Concurrent use with liqd paraffin. Rectal admin to patients with haemorrhoids or anal fissures. Do not use to soften inflammed or perforated ear drum.
Warnings / Precautions
 Pregnancy, lactation.
Adverse Reactions
 GI effects; skin rash; anorectal pain or bleeding following rectal administration.
Drug Interactions
 Enhances GI uptake of other drugs. Increases effect of anthraquinone laxatives. Increases incidence of adverse effects when given concurrently with aspirin.
See Below for More docusate sodium Drug Interactions
Mechanism of Actions
 Docusate sodium is an anionic surfactant which is considered to act primarily by increasing the penetration of fluid into the faeces. It may also have other effects on intestinal fluid secretion, and may act both as stimulant and as faecal softening agent. Docusate sodium is also used for softening wax in the ear.
ATC Classification
 A06AA02 - docusate sodium ; Belongs to the class of softeners, emollients laxatives.
Available As
  • Docusate Sodium 100 mg
  • Docusate 150 mg
  • Docusate Sodium 25 mg
  • Docusate 50 mg
  • Docusate Sodium 50 mg

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