Diphenylpraline

Indications
 Oral
Allergic conditions, Pruritic skin disorders
Adult: Up to 6 mg daily in 3-4 divided doses.
Contraindications
 Severe liver disease; avoid alcohol; premature infants or full-term neonates.
Warnings / Precautions
 May impair ability to drive and operate machinery. Angle-closure glaucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction; epilepsy; hepatic impairment. Elderly. Pregnancy and lactation.
Adverse Reactions
 Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation esp in child; psychomotor impairment; headache; palpitations and arrhythmias. Convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and GI disturbances, hypersensitivity reactions and blood disorders; tinnitus, hypotension; hair loss.
Drug Interactions
 Enhance effects of CNS depressants eg, alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Atropine, tricyclic antidepressants (TCAs), MAOIs. Can mask signs of ototoxicity caused by aminoglycosides. May antagonise the action of betahistine. Increased risk of seizure when used with bupropion. Concurrent use with mefloquine may lead to prolongation of the QT interval.
See Below for More diphenylpyraline hydrochloride Drug Interactions
Lab Interactions
 May interfere with skin testing.
Mechanism of Actions
 Diphenylpyraline, a piperidine derivative, is an antihistamine with antimuscarinic and significant sedative properties.
ATC Classification
 R06AA07 - diphenylpyraline ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines.
Available As
  • Diphenylpraline 1.5 mg
  • Diphenylpraline 2.5 mg
  • Diphenylpraline 5 mg

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