Indications |
Oral Staphylococcal infections resistant to benzylpenicillin Adult: 125-250 mg every 6 hr, doses may be doubled in severe infections. Child: 12.5-25 mg/kg/day in 4 divided doses. |
Contraindications |
Hypersensitivity to penicillins. |
Warnings / Precautions |
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Skin sensitization may occur on direct contact. Monitor serum K concentration, renal and hematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route; elderly; porphyria. |
Adverse Reactions |
Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; hemolytic anemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhea; antibiotic-associated colitis; hepatitis, cholestatic jaundice; agranulocytosis. Potentially Fatal: Anaphylaxis. |
Drug Interactions |
Probenecid prolongs T1/2 of dicloxacillin. Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants. See Below for More dicloxacillin Drug Interactions |
Lab Interactions |
May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria. |
Mechanism of Actions |
Dicloxacillin has antimicrobial action similar to benzylpenicillin and includes penicillinase-producing and non-penicillinase-producing staphylococci. It is active against streptococci eg, S. pneumoniae and S. pyogenes is < that of benzylpenicillin, but sufficient to be useful when these organisms are present with penicillin-resistant staphylococci. It is ineffective against E. faecalis. |
Administration |
Should be taken on an empty stomach. (Take on an empty stomach at least 1 hr before or 2 hr after meals.) |
ATC Classification |
J01CF01 - dicloxacillin ; Belongs to the class of beta-lactamase resistant penicillins. Used in the systemic treatment of infections. |
Available As |
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Dicloxacillin
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Dicloxacillin Containing Brands
Dicloxacillin is used in following diseases
Drug - Drug Interactions of Dicloxacillin
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