Indications |
Oral Allergic conditions Adult: As HCl: 4 mg tid adjusted as necessary. Usual dose range: 12-16 mg daily in 3-4 divided doses. Up to 32 mg daily may be used in some cases. Child: As HCl: 2-6 yr: 2 mg tid (max: 12 mg daily); 7-14 yr: 4 mg bid-tid (max: 16 mg daily). Elderly: Oral Treatment and prophylaxis of migraine and other vascular headaches Adult: As HCl: 4 mg, may repeat 30 minutes later. Not to exceed 8 mg within a 4-6-hr period. Maintenance dose: 4 mg every 4-6 hr. |
Contraindications |
Narrow-angle glaucoma; acute asthmatic attack; bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation. |
Warnings / Precautions |
Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy. |
Adverse Reactions |
Slight to moderate drowsiness, fatigue; dry mouth, GI upsets, nausea; appetite increase, wt gain and impaired alertness. |
Overdose Reactions |
Symptoms may vary from CNS depression or stimulation to convulsions, respiratory and cardiac arrest and death, especially in infants and children. Atropine-like and GI symptoms may also occur. Treatment is supportive and symptomatic. Emesis or gastric lavage, followed by activated charcoal to reduce drug absorption. Saline cathartics may be useful as they dilute bowel content quickly by osmosis. |
Drug Interactions |
Masks ototoxicity produced by aminoglycosides and antibiotics. Potentially Fatal: Potentiate CNS depressant actions of alcohol, barbiturates, sedatives, opioid analgesics and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and tricyclic antidepressants. See Below for More cyproheptadine Drug Interactions |
Lab Interactions |
Supression of diagnostic antigen skin test results and false-positive serum TCA screen. |
Mechanism of Actions |
Cyproheptadine is a sedating antihistamine with antimuscarinic, serotonin-antagonist and calcium-channel blocking properties. It competes for H1-receptor sites on effector cells in the GIT, blood vessels and resp tract. It is used as an appetite stimulant in some countries. Absorption: Absorbed from the GIT (oral). Metabolism: Completely hepatic. Excretion: Via urine (as conjugates); via faeces. |
Administration |
May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.) |
Storage Conditions |
Oral: Store at 15-25°C. |
ATC Classification |
R06AX02 - cyproheptadine ; Belongs to the class of other antihistamines for systemic use. |
Storage |
Oral: Store at 15-25°C. |
Available As |
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Cyproheptadine
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Cyproheptadine Containing Brands
Cyproheptadine is used in following diseases
Drug - Drug Interactions of Cyproheptadine
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