Cyclopentolate

Indications
 Ophthalmic
Mydriasis and cycloplegia for diagnosis
Adult: As hydrochloride: Instill 1 drop of a 0.5% solution into the affected eye/s repeated after 5-15 minutes. Deeply pigmented eyes are more resistant to pupillary dilatation and may require the use of 1% solution.
Child: Instill 1-2 drops of a 1% solution repeated after 5-15 minutes. Infants ≤3 mth: Not recommended.
Ophthalmic
Uveitis
Adult: As hydrochloride: Instill 1-2 drops of a 0.5% soln up to 4 times daily into the affected eye/s.
Ophthalmic
Iritis
Adult: As hydrochloride: Instill 1-2 drops of a 0.5% soln up to 4 times daily into the affected eye/s.
Contraindications
 Narrow-angle glaucoma.
Warnings / Precautions
 Intraocular pressure. May impair ability to drive for 1-2 hrs after mydriasis. Childn, elderly. Pregnancy, lactation.
Adverse Reactions
 Local irritation, hyperaemia, oedema and conjunctivitis, increased IOP (may precipitate narrow-angle glaucoma), systemic anticholinergic effects, severe CNS disturbances in child (rare).
Overdose Reactions
 Physical weakness, nausea, lightheadedness, changes in emotional state, unprovoked weeping, loss of equilibrium and tachycardia. Spontaneous recovery occurred within 1 hr to several days.
Mechanism of Actions
 Cyclopentolate is an anticholinergic. It produces dilatation of the pupil and paralysis of accommodation. Has a shorter duration of action than atropine.
Storage Conditions
 Ophthalmic: Store at 15-25°C.
ATC Classification
 S01FA04 - cyclopentolate ; Belongs to the class of anticholinergics used as mydriatics and cycloplegics.
Storage
 Ophthalmic: Store at 15-25°C.
Available As
  • Cyclopentolate 0.1%
  • Cyclopentolate 1%
  • Cyclopentolate 1% w/v
  • Cyclopentolate 10 mg

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