Clopidogrel

Indications
 Oral
Prophylaxis of thromboembolic disorders
Adult: 75 mg once daily.
CrCl (ml/min)Dosage Recommendation
5-15Use with caution.
Hepatic impairment: Severe hepatic impairment: Use with caution.
Oral
Acute coronary syndrome
Adult: For ST-elevation myocardial infarction: In combination with aspirin: 75 mg once daily. Patients ≤75 yr old may be given a loading dose of 300 mg. Continue treatment for up to 28 days. For unstable angina, non-ST-elevation myocardial infarction: Initial: 300 mg loading dose, followed by 75 mg once daily (with aspirin 75-325 mg once daily).
Contraindications
 Hypersensitivity. Active pathological bleeding. admin within 7 days after MI and ischaemic stroke, coagulation disorders. Lactation.
Warnings / Precautions
 Patients at risk of increased bleeding from trauma, surgery, or other pathological conditions; ulcer; renal and hepatic impairment; history of bleeding or haemostatic disorders. Pregnancy.
Adverse Reactions
 Dyspepsia, abdominal pain, nausea, vomiting, flatulence, constipation, gastritis, gastric and duodenal ulcers. GI upset, diarrhoea, paraesthesia, vertigo, headache, dizziness, pruritus and rashes.
Potentially Fatal: Bleeding disorders including GI and intracranial haemorrhage. Blood dyscrasias.
Overdose Reactions
 Prolonged bleeding time and subsequent bleeding complications. If quick reversal is required, platelet transfusion may be considered.
Drug Interactions
 Co-admin with NSAIDs may increase the risk of stomach and intestinal bleeding. High-dose clopidogrel may lead to increased warfarin levels thus increasing the risk of bleeding. High-dose clopidogrel may also inhibit P450 (2C9), thus interfering with the metabolism of phenytoin, tamoxifen, torasemide, fluvastatin and some NSAIDs. Avoid concurrent use of drugs that inhibit CYP2C19, including omeprazole, esomeprazole, cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine and ticlopidine.
See Below for More clopidogrel Drug Interactions
Mechanism of Actions
 Clopidogrel inhibits adenosine diphosphate (ADP) from binding to its receptor sites on the platelets and subsequent activation of glycoprotein GP IIb/IIIa complex thus preventing fibrinogen binding, platelet adhesion and aggregation.
Absorption: Rapidly but incompletely absorbed from the GI tract (oral).
Distribution: Protein-binding: Extensive.
Metabolism: Hepatic: Extensive; converted to inactive carboxylic acid derivative and thiol derivative (active).
Excretion: Via urine and faeces (as metabolites and unchanged drug).
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 B01AC04 - clopidogrel ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Storage
 Oral: Store at 25°C.
Available As
  • Clopidogrel 150 mg
  • Clopidogrel 300 mg
  • Clopidogrel 75 mg
  • Clopidogrel bisuirate 75 mg

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    One Response to Clopidogrel

    1. November 21, 2014 at 3:25 pm #

      Excellent app.i love it

      Reply

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