Clopamide

Indications
 Oral
Oedema
Adult: 10-40 mg daily or on alternate days, reduce frequency for maintenance.
Oral
Hypertension
Adult: 5-10 mg daily alone or in conjunction with other antihypertensives.
Contraindications
 Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia.
Warnings / Precautions
 Fluid and electrolyte disturbances; hepatic cirrhosis; gout; diabetes mellitus. Elderly; severe heart failure; renal or hepatic impairment. Monitor blood glucose concentrations in patients taking antidiabetics. Pregnancy and lactation.
Adverse Reactions
 Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
Drug Interactions
 Digitalis glycosides; drugs that prolong QT interval; other antihypertensives; competitive muscle relaxants; pressor amines; corticosteroids, corticotrophin; β2-agonists, α-blockers; ACE inhibitors; NSAIDs; alcohol, barbiturates; opioids; lithium; allopurinol; tetracyclines; carbenoxolone; hypoglycaemics.
See Below for More clopamide Drug Interactions
Mechanism of Actions
 Clopamide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of Na and chloride ions and consequently of water. It also reduces the glomerular filtration rate.
Onset: 1-2 hrs.
Duration: Up to 24 hrs.
Storage Conditions
 Oral: Store below 30°C.
ATC Classification
 C03BA03 - clopamide ; Belongs to the class of low-ceiling sulfonamide diuretics.
Storage
 Oral: Store below 30°C.
Available As
  • Clopamide 20 mg

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