Clemastine

Indications
Oral
Allergic conditions
Adult: 1 mg bid. Up to 6 g daily for urticaria and angioedema.
Child: 6-12 yr: 0.5-1 mg bid; 3-6 yr: 0.5 mg bid; 1-3 yr: 0.25-0.5 mg bid.
Parenteral
Prophylaxis of acute allergic conditions
Adult: 2 mg/day via IV inj.
Child: 25 mcg/kg IM in 2 divided doses.
Parenteral
Acute allergic reactions
Adult: 4 mg IM or slow IV inj daily.
Contraindications
Hypersensitivity; narrow-angle glaucoma; neonates, lactation; porphyria.
Warnings / Precautions
Tasks requiring mental alertness; bladder neck obstruction; CV disease; stenosing peptic ulcer; increased intraocular pressure; hyperthyroidism; symptomatic prostate cancer; elderly, pregnancy.
Adverse Reactions
Drowsiness, CNS depression, dizziness, sedation; diarrhoea, nausea, vomiting; blurred vision, thickened respiratory secretions; tinnitus.
Overdose Reactions
CNS depression to stimulation with atropine-like signs and symptoms: dry mouth, fixed dilated pupils, flushing and GI symptoms. Empty stomach by inducing vomiting with water or milk or gastric lavage with isotonic and 1/2 isotonic saline. Saline cathartics, such as milk of magnesia, draw water into the bowel by osmosis and help in rapid dilution of bowel content. Stimulants should not be used. Hypotension may be treated with vasopressors.
Drug Interactions
Antagonises effects of cholinergic agents and neuroleptics.
Potentially Fatal: Severe sedation and CNS depression may occur when used concomitantly with alcohol or other CNS depressants.
See Below for More clemastine Drug Interactions
Mechanism of Actions
Clemastine competitively blocks H1-receptors sites on effector cells of the GI tract, blood vessels and respiratory tract.
Absorption: Rapidly and almost completely absobed from the GI tract (oral); peak plasma concentrations after 2-4 hr.
Excretion: Via urine (as unchanged drug and metabolites); 21 hr (elimination half-life).
Administration
May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
Storage Conditions
Oral: Store below 25°C. Parenteral: Store below 25°C.
ATC Classification
D04AA14 - clemastine ; Belongs to the class of topical antihistamines used in the treatment of pruritus.
R06AA04 - clemastine ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines.
Storage
Oral: Store below 25°C. Parenteral: Store below 25°C.
Available As
  • Clemastine Fumarate 0.1 mg
  • Clemastine 0.1 mg
  • Clemastine Fumarate 0.5 mg
  • Clemastine 0.67 mg
  • Clemastine Fumarate 1 mg
  • Clemastine 1 mg
  • Clemastine 1.34 mg
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