Indications |
Oral Allergic conditions Adult: 1 mg bid. Up to 6 g daily for urticaria and angioedema. Child: 6-12 yr: 0.5-1 mg bid; 3-6 yr: 0.5 mg bid; 1-3 yr: 0.25-0.5 mg bid. Parenteral Prophylaxis of acute allergic conditions Adult: 2 mg/day via IV inj. Child: 25 mcg/kg IM in 2 divided doses. Parenteral Acute allergic reactions Adult: 4 mg IM or slow IV inj daily. |
Contraindications |
Hypersensitivity; narrow-angle glaucoma; neonates, lactation; porphyria. |
Warnings / Precautions |
Tasks requiring mental alertness; bladder neck obstruction; CV disease; stenosing peptic ulcer; increased intraocular pressure; hyperthyroidism; symptomatic prostate cancer; elderly, pregnancy. |
Adverse Reactions |
Drowsiness, CNS depression, dizziness, sedation; diarrhoea, nausea, vomiting; blurred vision, thickened respiratory secretions; tinnitus. |
Overdose Reactions |
CNS depression to stimulation with atropine-like signs and symptoms: dry mouth, fixed dilated pupils, flushing and GI symptoms. Empty stomach by inducing vomiting with water or milk or gastric lavage with isotonic and 1/2 isotonic saline. Saline cathartics, such as milk of magnesia, draw water into the bowel by osmosis and help in rapid dilution of bowel content. Stimulants should not be used. Hypotension may be treated with vasopressors. |
Drug Interactions |
Antagonises effects of cholinergic agents and neuroleptics. Potentially Fatal: Severe sedation and CNS depression may occur when used concomitantly with alcohol or other CNS depressants. See Below for More clemastine Drug Interactions |
Mechanism of Actions |
Clemastine competitively blocks H1-receptors sites on effector cells of the GI tract, blood vessels and respiratory tract. Absorption: Rapidly and almost completely absobed from the GI tract (oral); peak plasma concentrations after 2-4 hr. Excretion: Via urine (as unchanged drug and metabolites); 21 hr (elimination half-life). |
Administration |
May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.) |
Storage Conditions |
Oral: Store below 25°C. Parenteral: Store below 25°C. |
ATC Classification |
D04AA14 - clemastine ; Belongs to the class of topical antihistamines used in the treatment of pruritus. R06AA04 - clemastine ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines. |
Storage |
Oral: Store below 25°C. Parenteral: Store below 25°C. |
Available As |
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Clemastine
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Clemastine Containing Brands
Clemastine is used in following diseases
Drug - Drug Interactions of Clemastine
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