Cefuroxime

Indications
Oral
Uncomplicated urinary tract infections
Adult: 125 mg bid.
Oral
Respiratory tract infections
Adult: 250-500 mg bid.
Child: >3 mth: 125 mg bid or 10 mg/kg bid. Max dose: 250 mg daily.
Oral
Uncomplicated gonorrhoea
Adult: 1 g as a single dose. 1 g oral probenecid may be given concurrently.
Oral
Otitis media
Child: >2 yr: 250 mg bid or 15 mg/kg bid up to 500 mg daily.
Intravenous
Meningitis
Adult: 3 g every 8 hr.
Child: 200-240 mg/kg/day in 3-4 divided doses, decreased to 100 mg/kg/day after 3 days or once symptoms have improved. Neonate: 100 mg/kg/day, decreased to 50 mg/kg/day when control has been achieved.
Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid.
CrCl (ml/min)Dosage Recommendation
10-20750 mg bid.
<10750 mg once daily.

Intramuscular
Gonorrhoea
Adult: 1.5 mg as a single dose divided between 2 inj sites. 1 g oral probenecid may be given concurrently.
Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid.
CrCl (ml/min)Dosage Recommendation
10-20750 mg bid.
<10750 mg once daily.

Parenteral
Prophylaxis of surgical infections
Adult: 1.5 g IV before the procedure followed by 750 mg IM every 8 hr for up to 24-48 hr depending on the procedure. For total joint replacement, 1.5 g of cefuroxime may be mixed with methylmethacrylate cement.
Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid.
CrCl (ml/min)Dosage Recommendation
10-20750 mg bid.
<10750 mg once daily.

Parenteral
Susceptible infections
Adult: 750 mg every 8 hr given as deep IM or slow IV inj over 3-5 min or IV infusion, increased to 1.5 g every 6-8 hr in severe infections.
Child: 30-60 mg/kg/day, may increase to 100 mg/kg/day if necessary. To be given in 3-4 divided doses or 2-3 divided doses in neonates.
Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid.
CrCl (ml/min)Dosage Recommendation
10-20750 mg bid.
<10750 mg once daily.


Incompatibility: Incompatible with aminoglycosides.
Contraindications
Hypersensitivity to cephalosporins.
Warnings / Precautions
Severe renal impairment; pregnancy, lactation; hypersensitivity to penicillins.
Adverse Reactions
Large doses can cause cerebral irritation and convulsions; nausea, vomiting, diarrhoea, GI disturbances; erythema multiforme, Stevens-Johnson syndrome, epidermal necrolysis.
Potentially Fatal: Anaphylaxis, nephrotoxicity, pseudomembranous colitis.
Drug Interactions
Probenecid decreases renal clearance of cefuroxime.
Potentially Fatal: Nephrotoxicity with aminoglycosides and furosemide.
See Below for More cefuroxime Drug Interactions
Lab Interactions
False-positive for Coombs' test. It may interfere with urine-sugar estimation.
Food Interactions
Oral cefuroxime axetil is better absorbed after food intake.
Mechanism of Actions
Cefuroxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Absorbed from the GI tract with peak plasma concentrations after 2-3 hr (oral); may be enhanced by the presence of food.
Distribution: Pleural and synovial fluid, sputum, bone and aqueous fluids; CSF (therapeutic concentrations). Crosses the placenta and enters breast milk. Protein-binding: Up to 50%.
Metabolism: Rapidly hydrolysed (intestinal mucosa and blood).
Excretion: Via the urine by glomerular filtration and renal tubular secretion (as unchanged); via bile (small amounts); 70 min (elimination half-life); prolonged in neonates and renal impairment.
Administration
Should be taken with food.
Storage Conditions
Intramuscular: Store at 15-30°C. Intravenous: Store at 15-30°C. Oral: Store at 15-30°C. Parenteral: Inj: Store at 15-30°C.
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Storage
Intramuscular: Store at 15-30°C. Intravenous: Store at 15-30°C. Oral: Store at 15-30°C. Parenteral: Inj: Store at 15-30°C.
Available As
  • Cefuroxime 100 mg
  • Cefuroxime Axetil 100 mg
  • Cefuroxime 1000 mg
  • Cefuroxime Sodium 125 mg
  • Cefuroxime Axetil 125 mg
  • Cefuroxime 125 mg
  • Cefuroxime 1500 mg
  • Cefuroxime Axetil 1500 mg
  • Cefuroxime Sodium 1500 mg
  • Cefuroxime 200 mg
  • Cefuroxime Axetil 200 mg
  • Cefuroxime 250 mg
  • Cefuroxime Sodium 250 mg
  • Cefuroxime Axetil 250 mg
  • Cefuroxime 450 mg
  • Cefuroxime Axetil 50 mg
  • Cefuroxime 50 mg
  • Cefuroxime Sodium 500 mg
  • Cefuroxime 500 mg
  • Cefuroxime Axetil 500 mg
  • Cefuroxime Sodium 750 mg
  • Cefuroxime 750 mg
  • Cefuroxime Axetil 750 mg
  • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Cefuroxime


    Cefuroxime Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Centra (250 mg) G Nine Pharmaceuticals 1 Tablet
    ₹ 5.30
    10 Tablet
    ₹ 53.00
  • More Information Cefuroxime 250 mg
  • See Brands having above combination
    Tablet Cefos (500 mg) Osper Pharmaceutics Pvt. Ltd. 1 Tablet
    ₹ 5.50
    40 Tablet
    ₹ 220.00
  • More Information Cefuroxime 500 mg
  • See Brands having above combination
    Tablet Evercef (250 mg) Diabetes (Orchid Chemicals & Pharmaceuticals Ltd.) 1 Tablet
    ₹ 4.03
    40 Tablet
    ₹ 161.00
  • More Information Cefuroxime 250 mg
  • See Brands having above combination
    Tablet Furomax (500 mg) Biomax Biotechnics Pvt Ltd 1 Tablet
    ₹ 4.80
    10 Tablet
    ₹ 48.00
  • More Information Cefuroxime 500 mg
  • See Brands having above combination
    Tablet Glyph ZM (250 mg) Globus Remedies Ltd 1 Tablet
    ₹ 3.50
    100 Tablet
    ₹ 350.00
  • More Information Cefuroxime 250 mg
  • See Brands having above combination
    Tablet Lextum (250 mg) Lexus (India) Organics 1 Tablet
    ₹ 3.40
    10 Tablet
    ₹ 34.00
  • More Information Cefuroxime 250 mg
  • See Brands having above combination
    Tablet Maidoxime (125 mg) Maiden Pharmaceuticals Limited 1 Tablet
    ₹ 4.20
    10 Tablet
    ₹ 42.00
  • More Information Cefuroxime 125 mg
  • See Brands having above combination
    Syrup Nextrim DS (30 ml) Nexus (India) 1 ml
    ₹ 4.17
    30 ml
    ₹ 125.00
  • More Information Cefuroxime 125 mg
  • See Brands having above combination
    Tablet Nortum O (500 mg) Normak Laboratories 1 Tablet
    ₹ 3.50
    100 Tablet
    ₹ 350.00
  • More Information Cefuroxime 500 mg
  • See Brands having above combination
    Tablet Wyceft Tab (250 mg) Vostok & Wilcure Remedies 1 Tablet
    ₹ 2.60
    10 Tablet
    ₹ 26.00
  • More Information Cefuroxime Axetil 250 mg
  • See Brands having above combination
    Pages: 1 2 3 4 5 6 7 8 ... 98 99 100 Next
    Cefuroxime is used in following diseases

    We are Developing Our database, More results coming soon.

    Pages: 1 2 3 4 5 6 7 8 ... 98 99 100 Next
    Drug - Drug Interactions of Cefuroxime
    Interaction
    Moderate, Consider therapy modification Magnesium carbonate, calcium carbonate, and folic acid vs Cefuroxime
    Moderate, Consider therapy modification Aluminum hydroxide, magnesium hydroxide, and simethicone vs Cefuroxime
    Moderate, Consider therapy modification Citric acid bladder mixture vs Cefuroxime
    Moderate, Consider therapy modification Calcium carbonate and simethicone vs Cefuroxime
    Moderate, Consider therapy modification Calcium carbonate vs Cefuroxime
    Moderate, Consider therapy modification Magnesium hydroxide vs Cefuroxime
    Moderate, Consider therapy modification Aluminum hydroxide and magnesium carbonate vs Cefuroxime
    Minor, Monitor Therapy Cimetidine vs Cefuroxime
    Moderate, Consider therapy modification Famotidine, calcium carbonate, and magnesium hydroxide vs Cefuroxime
    Minor, Monitor Therapy Famotidine, calcium carbonate, and magnesium hydroxide vs Cefuroxime
    Pages: 1 2 3 Next