Cefprozil (Cefproxil)

Indications
 Oral
Skin and soft tissue infections, Susceptible infections
Adult: 500 mg/day as a single dose or in 2 divided doses, increased to 500 mg bid if necessary.
Child: 20 mg/kg/day once or twice daily, up to a max dose of 500 mg once daily, if necessary, bid for otitis media.
CrCl (ml/min)Dosage Recommendation
<30Half normal dose.


Special Populations: Dose reduction in renal impairment. CrCl <30 mL/min: 1/2 the standard dose.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and haematologic status. Pregnancy, lactation.
Adverse Reactions
 Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
Potentially Fatal: Pseudomembranous colitis.
Drug Interactions
 Renal excretion delayed by probenecid. Decreases contraceptive effect of oestrogen-containing oral contraceptives.
See Below for More cefprozil Drug Interactions
Lab Interactions
 Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
Mechanism of Actions
 Cefprozil inhibits cell wall synthesis and has activity against a broad range of gram-positive and gram-negative bacteria.
Absorption: Well absorbed from the GI tract. Bioavailability: 90-95%.
Distribution: 35-45% bound to plasma proteins. Widely distributed in the body tissues.
Excretion: Plasma half-life: 1-1.4 hr; prolonged in renal impairment. About 60% excreted unchanged in the urine.
Administration
 May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
ATC Classification
 J01DC10 - cefprozil ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Available As
  • Cefprozil (Cefproxil) 250 mg
  • Cefprozil (Cefproxil) 500 mg

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