Indications |
Oral Susceptible infections Adult: 200-400 mg/day as a single dose or in 2 divided doses. Child: 8 mg/kg/day as a single dose or in 2 divided doses; <6 mth: Not recommended. Treatment should be continued for 48 hr after disappearance of symptoms. Renal impairment: Dose reduction is necessary.
Oral Uncomplicated gonorrhoea Adult: 400 mg as a single dose. Renal impairment: Dose reduction is necessary.
Special Populations: Reduce dose in renal impairment. |
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Contraindications |
Hypersensitivity to cephalosporin. | ||||||||
Warnings / Precautions |
History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease. | ||||||||
Adverse Reactions |
Diarrhoea, nausea, vomiting, abdominal pain; headache, dizziness, thrombocytopenia, eosinophilia. Potentially Fatal: Pseudomembranous colitis. |
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Drug Interactions |
Increased concentrations with probenecid. Potentially Fatal: May increase prothrombin time with anticoagulants. See Below for More cefixime Drug Interactions |
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Lab Interactions |
False-positive serum or urine creatinine with Jaffe reaction. | ||||||||
Food Interactions |
Absorption delayed in the presence of food. | ||||||||
Mechanism of Actions |
Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption: Only 40-50% is absorbed from the GI tract (oral); rate may be decreased if taken with food. Greater absorption from oral suspension than tablets. Distribution: Bile, urine (high concentrations); crosses the placenta. Protein-binding: 65%. Excretion: 20% of an oral dose excreted via urine unchanged; 60% nonrenal elimination; some is excreted via the faeces from the bile. Substantially removed by dialysis. |
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Administration |
May be taken with or without food. (May be taken w/ food or milk to reduce GI discomfort.) |
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Storage Conditions |
Oral: Store below 25°C. | ||||||||
ATC Classification |
J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections. | ||||||||
Storage |
Oral: Store below 25°C. | ||||||||
Available As |
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Cefixime
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Cefixime is used in following diseases
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