Cefixime

Indications
Oral
Susceptible infections
Adult: 200-400 mg/day as a single dose or in 2 divided doses.
Child: 8 mg/kg/day as a single dose or in 2 divided doses; <6 mth: Not recommended. Treatment should be continued for 48 hr after disappearance of symptoms.
Renal impairment: Dose reduction is necessary.
CrCl (ml/min)Dosage Recommendation
<20Max: 200 mg daily.

Oral
Uncomplicated gonorrhoea
Adult: 400 mg as a single dose.
Renal impairment: Dose reduction is necessary.
CrCl (ml/min)Dosage Recommendation
<20Max: 200 mg daily.


Special Populations: Reduce dose in renal impairment.
Contraindications
Hypersensitivity to cephalosporin.
Warnings / Precautions
History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease.
Adverse Reactions
Diarrhoea, nausea, vomiting, abdominal pain; headache, dizziness, thrombocytopenia, eosinophilia.
Potentially Fatal: Pseudomembranous colitis.
Drug Interactions
Increased concentrations with probenecid.
Potentially Fatal: May increase prothrombin time with anticoagulants.
See Below for More cefixime Drug Interactions
Lab Interactions
False-positive serum or urine creatinine with Jaffe reaction.
Food Interactions
Absorption delayed in the presence of food.
Mechanism of Actions
Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Only 40-50% is absorbed from the GI tract (oral); rate may be decreased if taken with food. Greater absorption from oral suspension than tablets.
Distribution: Bile, urine (high concentrations); crosses the placenta. Protein-binding: 65%.
Excretion: 20% of an oral dose excreted via urine unchanged; 60% nonrenal elimination; some is excreted via the faeces from the bile. Substantially removed by dialysis.
Administration
May be taken with or without food. (May be taken w/ food or milk to reduce GI discomfort.)
Storage Conditions
Oral: Store below 25°C.
ATC Classification
J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Storage
Oral: Store below 25°C.
Available As
  • Cefixime 10 mg
  • Cefixime 100 mg
  • Cefixime Trihydrate 100 mg
  • Cefixime 1000 mg
  • Cefixime 12 gm
  • Cefixime 125 mg
  • Cefixime 15 gm
  • Cefixime 15 mg
  • Cefixime 2 mg
  • Cefixime 200 mg
  • Cefixime Trihydrate 200 mg
  • Cefixime 25 mg
  • Cefixime 250 mg
  • Cefixime 30 mg
  • Cefixime Trihydrate 400 mg
  • Cefixime 400 mg
  • Cefixime 50 mg
  • Cefixime Trihydrate 50 mg
  • Cefixime 500 mg
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    Cefixime Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Alcef O (100 mg) Alpa/Starry Health Care Pvt. Ltd. 1 Tablet
    ₹ 1.20
    10 Tablet
    ₹ 12.00
  • More Information Cefixime 100 mg
  • See Brands having above combination
    Tablet C Fex (200 mg) Alar Laboratories Ltd 1 Tablet
    ₹ 0.78
    200 Tablet
    ₹ 155.00
  • More Information Cefixime Trihydrate 200 mg
  • See Brands having above combination
    Tablet Brufix (200 mg) Brawn Laboratories Ltd. 1 Tablet
    ₹ 1.60
    40 Tablet
    ₹ 64.00
  • More Information Cefixime 200 mg
  • See Brands having above combination
    Tablet Ceom (100 mg) Almed Drugs (P) Ltd. 1 Tablet
    ₹ 1.60
    10 Tablet
    ₹ 16.00
  • More Information Cefixime 100 mg
  • See Brands having above combination
    Tablet Cembol (100+30+LB) Cadila Pharmaceuticals Ltd. 1 Tablet
    ₹ 1.01
    60 Tablet
    ₹ 60.54
  • More Information Ambroxol 30 mg
  • More Information Cefixime 100 mg
  • More Information Lacto Bacillus Sporegens 30 million spores
  • See Brands having above combination
    Tablet Cembol (200+60+LB) Cadila Pharmaceuticals Ltd. 1 Tablet
    ₹ 1.88
    60 Tablet
    ₹ 112.65
  • More Information Ambroxol 60 mg
  • More Information Lactic Acid Bacillus 60 million spores
  • More Information Cefixime 200 mg
  • See Brands having above combination
    Tablet Cefstat (200 mg) Kaiser Pharmaceuticals 1 Tablet
    ₹ 1.00
    10 Tablet
    ₹ 10.00
  • More Information Cefixime Trihydrate 200 mg
  • See Brands having above combination
    Tablet Cefal-O (100 mg) Mercury Laboratories Ltd. 1 Tablet
    ₹ 0.83
    100 Tablet
    ₹ 82.93
  • More Information Cefixime 100 mg
  • See Brands having above combination
    Tablet Euroxim DT (50+LB) Euro Organics 1 Tablet
    ₹ 0.70
    10 Tablet
    ₹ 7.00
  • More Information Cefixime 50 mg
  • More Information Lacto Bacillus Sporegens 20 million spores
  • See Brands having above combination
    Tablet Iofix (100 mg) Dion Pharmaceuticals 1 Tablet
    ₹ 0.90
    10 Tablet
    ₹ 9.00
  • More Information Cefixime 100 mg
  • See Brands having above combination
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    Cefixime is used in following diseases

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    Drug - Drug Interactions of Cefixime
    Interaction
    Moderate, Consider therapy modification Cefixime vs Typhoid Vaccine
    Minor, Monitor Therapy Cefixime vs Probenecid
    Major, Avoid combination Cefixime vs BCG