Cefalexin

Indications
 Oral
Susceptible infections
Adult: 1-2 g daily given in divided doses at 6-, 8-, 12-hr intervals, increased to 6 g in deep-seated infections.
Child: 25-100 mg/kg daily in divided doses. Max: 4 g daily.
CrCl (ml/min)Dosage Recommendation
40-50Max: 3 g daily.
10-40Max: 1.5 g daily.
<10Max: 750 mg daily.

Oral
Prophylaxis of recurrent urinary tract infections
Adult: 125 mg at night.
CrCl (ml/min)Dosage Recommendation
40-50Max: 3 g daily.
10-40Max: 1.5 g daily.
<10Max: 750 mg daily.


Special Populations: Reduce dose in patients with severe renal impairment. Parenteral admin should be considered when high doses are required.
Contraindications
 Hypersensitivity to cephalosporins.
Warnings / Precautions
 Hypersensitivity to penicillins; pseudomembranous colitis; renal failure; pregnancy and lactation.
Adverse Reactions
 Pain at inj site; hypersensitivity; GI disturbances; eosinophilia, neutropenia, leucopenia, thrombocytopenia.
Potentially Fatal: Anaphylactic reactions; nephrotoxicity.
Drug Interactions
 Probenecid produces higher and prolonged serum levels.
Potentially Fatal: Increased nephrotoxicity with aminoglycosides and furosemide.
See Below for More cefalexin Drug Interactions
Lab Interactions
 False-positive for urine sugar, Coomb's test and serum or creatinine with Jaffe reaction.
Food Interactions
 Rate of absorption is delayed by food.
Mechanism of Actions
 Cefalexin binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Almost completely absorbed from the GI tract with peak plasma concentrations after 1 hr (oral); may be delayed if taken with food.
Distribution: Widely distributed but does not penetrate the CSF; bile (therapeutic concentrations). Crosses the placenta and enters the breast milk (small amounts). Protein-binding: Up to 15%
Metabolism: Not metabolised.
Excretion: Via the urine within 6 hr by glomerular filtration and renal tubular secretion (>80% as unchanged); via the bile. May be removed by haemodialysis and peritoneal dialysis; 1 hr (elimination half-life).
Administration
 May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 J01DB01 - cefalexin ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
Storage
 Oral: Store at 25°C.
Available As
  • Cefalexin 100 mg
  • Cefalexin 125 mg
  • Cefalexin 250 mg
  • Cefalexin 375 mg
  • Cefalexin 500 mg
  • Cefalexin 6 mg
  • Cefalexin 750 mg

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