Cefadroxil

Indications
Oral
Uncomplicated lower urinary tract infections
Adult: 1-2 g daily as a single or 2 divided doses.
Child: >6 yr: 500 mg bid; 1-6 yr: 250 mg bid; <1 yr: 25 mg/kg daily in divided doses.
CrCl (ml/min)Dosage Recommendation
26-500.5-1 g bid.
11-250.5-1 g once daily.
≤100.5-1 g every 36 hr.

Oral
Skin and skin structure infections
Adult: 1 g/day in single or divided doses.
Child: 30 mg/kg/day in equally divided doses every 12 hr.
CrCl (ml/min)Dosage Recommendation
26-500.5-1 g bid.
11-250.5-1 g once daily.
≤100.5-1 g every 36 hr.

Oral
Pharyngitis
Adult: For treatment of group A β-haemolytic streptococcal pharyngitis and tonsillitis: 1 g/day in single or divided doses for 10 days.
Child: 30 mg/kg/day in equally divided doses every 12 hr for at least 10 days.
CrCl (ml/min)Dosage Recommendation
26-500.5-1 g bid.
11-250.5-1 g once daily.
≤100.5-1 g every 36 hr.

Oral
Tonsillitis
Adult: For treatment of group A β-haemolytic streptococcal pharyngitis and tonsillitis: 1 g/day in single or divided doses for 10 days.
Child: 30 mg/kg/day in equally divided doses every 12 hr for at least 10 days.
CrCl (ml/min)Dosage Recommendation
26-500.5-1 g bid.
11-250.5-1 g once daily.
≤100.5-1 g every 36 hr.


Special Populations: In infections with beta-hemolytic streptococci, treatment should be continued for at least 10 days. Renal impairment: Dose reduction based on creatinine clearance.
Contraindications
Hypersensitivity to cephalosporins.
Warnings / Precautions
Impaired renal function; pregnancy and lactation.
Adverse Reactions
Nausea, vomiting, diarrhoea, abdominal discomfort; skin rash, angioedema; elevated liver enzyme values; superinfection with resistant organisms especially candida.
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Drug Interactions
Prothrombin time prolonged; bleeding may occur when taken with anticoagulants. Decreased elimination with probenecid.
See Below for More cefadroxil Drug Interactions
Lab Interactions
False-positive results for direct Coombs' test and urine sugar (Benedict's, Fehling's or other reagents but not with enzyme-based methods). Interferes with Jaffe method of measuring creatinine.
Mechanism of Actions
Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1.5-2 hr.
Distribution: Body tissues and fluids (wide); crosses the placenta and enters breast milk. Protein-binding: 20%.
Excretion: Via urine by glomerular filtration and tubular secretion (90% as unchanged); 1.5 hr (elimination half-life), prolonged in renal impairment. Removed by dialysis.
Administration
May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
Storage Conditions
Oral: Store at 15-30°C.
ATC Classification
J01DB05 - cefadroxil ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
Storage
Oral: Store at 15-30°C.
Available As
  • Cefadroxil 100 mg
  • Cefadroxil 1000 mg
  • Cefadroxil 125 mg
  • Cefadroxil 15 gm
  • Cefadroxil 200 mg
  • Cefadroxil 250 mg
  • Cefadroxil 50 mg
  • Cefadroxil 500 mg
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    Cefadroxil Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Acidrox (250 mg) Acichem Laboratories 1 Tablet
    ₹ 0.40
    100 Tablet
    ₹ 40.00
  • More Information Cefadroxil 250 mg
  • See Brands having above combination
    Tablet Acidrox Kid (125 mg) Acichem Laboratories 1 Tablet
    ₹ 0.20
    100 Tablet
    ₹ 20.00
  • More Information Cefadroxil 125 mg
  • See Brands having above combination
    Tablet Amdrox (125 mg) Maiden Pharmaceuticals Limited 1 Tablet
    ₹ 0.80
    10 Tablet
    ₹ 8.00
  • More Information Cefadroxil 125 mg
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    Tablet Bid LB (125 mg) Merck Limited 1 Tablet
    ₹ 0.94
    100 Tablet
    ₹ 93.80
  • More Information Cefadroxil 125 mg
  • More Information Lacto Bacillus Sporegens 45 million spores
  • See Brands having above combination
    Tablet Cefavir DT (125 mg) East African (I) Remedies (P) Ltd. 1 Tablet
    ₹ 0.70
    10 Tablet
    ₹ 7.00
  • More Information Cefadroxil 125 mg
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    Tablet Cefadron-LB (125 mg) Agron Remedies Pvt Ltd 1 Tablet
    ₹ 0.88
    100 Tablet
    ₹ 87.98
  • More Information Cefadroxil 125 mg
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    Tablet Cedol DT (500 mg) Ultimedix 1 Tablet
    ₹ 0.35
    10 Tablet
    ₹ 3.50
  • More Information Cefadroxil 500 mg
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    Capsule Cidaxil Cap (250 mg) Neon Laboratories Ltd 1 Capsule
    ₹ 0.38
    10 Capsule
    ₹ 3.76
  • More Information Cefadroxil 250 mg
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    Syrup Drocef (30 ml) Hamax Pharmaceuticals 1 ml
    ₹ 0.52
    30 ml
    ₹ 15.72
  • More Information Cefadroxil 125 mg
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    Syrup Eliminate DS (30 ml) (125 mg) Zydus Cadila Healthcare Ltd 1 ml
    ₹ 0.68
    30 ml
    ₹ 20.36
  • More Information Cefadroxil 125 mg
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    Cefadroxil is used in following diseases

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    Drug - Drug Interactions of Cefadroxil
    Interaction
    Moderate, Consider therapy modification Cefadroxil vs Typhoid Vaccine
    Minor, Monitor Therapy Cefadroxil vs Probenecid
    Major, Avoid combination Cefadroxil vs BCG