Cefaclor

Indications
 Oral
Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media
Adult: As monohydrate: 250-500 mg every 8 hr. Max: 4 g daily.
Child: >1 mth: 20 mg/kg daily in 3 divided doses, increased to 40 mg/kg daily if necessary, <1 yr: 62.5 mg tid, 1-5 yr: 125 mg tid, >5 yr: 250 mg tid.

Special Populations: Renal impairment: No dose change required.
Contraindications
 Known hypersensitivity to cephalosporins.
Warnings / Precautions
 Severe renal impairment; history of allergy to penicillin; pregnancy, lactation.
Adverse Reactions
 Allergic reactions; diarrhoea, nausea, vomiting; candidiasis, eosinophilia; elevated transaminases.
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Drug Interactions
 Probenecid slows tubular excretion.
Potentially Fatal: May enhance nephrotoxicity of aminoglycosides and furosemide. Bleeding may occur if taken with anticoagulants.
See Below for More cefaclor Drug Interactions
Lab Interactions
 False-positive results for direct Coombs' test and urine sugar (Benedict's, Fehling's or other reagents but not with enzyme-based methods). Interferes with Jaffe method of measuring creatinine.
Food Interactions
 Plasma levels slightly reduced.
Mechanism of Actions
 Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.
Absorption: Well absorbed from the GIT (oral); rate but not extent of absorption is altered by food.
Distribution: Widely distributed; crosses the placenta and enters breast milk (low concentrations). Protein-binding: 25%
Excretion: Via the urine by the kidneys within 8 hrs (as 85% unchanged); the greater part of the dose within 2 hrs. Elimination half-life: 0.5-1 hr, slightly prolonged in renal impairment. May be removed by haemodialysis.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 15-30°C.
ATC Classification
 J01DC04 - cefaclor ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Storage
 Oral: Store at 15-30°C.
Available As
  • Cefaclor 125 mg
  • Cefaclor 15 gm
  • Cefaclor 187 mg
  • Cefaclor 250 mg
  • Cefaclor 375 mg
  • Cefaclor 50 mg
  • Cefaclor 500 mg
  • Cefaclor 750 mg

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